Expression of WDR75 in cancer - Summary

GENERAL INFORMATION
Gene name	WDR75
Gene description	WD repeat domain 75
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues, additional positivity in immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA038199
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA038199

GENE INFORMATION
Gene name	WDR75 (HGNC Symbol)
Synonyms	FLJ12519, NET16, UTP17
Description	WD repeat domain 75 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q32.2
Chromosome location (bp)	189441433 - 189475565
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115368 (version 83.38)
Entrez gene	84128
UniProt	Q8IWA0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWA0
Antibodypedia	WDR75 antibodies

PROTEIN BROWSER

WDR75-001	WDR75-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WDR75-001 ENSP00000314193 ENST00000314761	Q8IWA0 [Direct mapping] WD repeat-containing protein 75 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000124 [SAGA complex] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016573 [histone acetylation] GO:0044822 [poly(A) RNA binding] GO:1903146 [regulation of mitophagy] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	830 aa 94.5 kDa	No	0
WDR75-201 ENSP00000486831 ENST00000631047	F8WE20 [Direct mapping] WD repeat-containing protein 75 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	89 aa 10.1 kDa	No	0