Expression of REG1A in cancer - Summary - The Human Protein Atlas

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REG1A

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	REG1A
Gene description	Regenerating islet-derived 1 alpha
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (colorectal cancer, pancreatic cancer, stomach cancer)
HPA (cell line):	Cell line enhanced (EFO-21, HDLM-2, RPMI-8226, SH-SY5Y, U-2 OS)
HPA (normal tissue):	Group enriched (duodenum, pancreas, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in exocrine pancreas and the small intestine.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 3 antibodies. HPA045549 , HPA045579 , CAB025138
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (colorectal cancer, pancreatic cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045549	HPA045579	CAB025138

GENE INFORMATION
Gene name	REG1A (HGNC Symbol)
Synonyms	PSP, PSPS, PSPS1, PTP, REG
Description	Regenerating islet-derived 1 alpha (HGNC Symbol)
Entrez gene summary	This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p12
Chromosome location (bp)	79120362 - 79123419
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115386 (version 83.38)
Entrez gene	5967
UniProt	P05451 (UniProt - Evidence at protein level)
neXtProt	NX_P05451
Antibodypedia	REG1A antibodies

PROTEIN BROWSER

REG1A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
REG1A-001 ENSP00000233735 ENST00000233735	P05451 [Direct mapping] Lithostathine-1-alpha Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell proliferation] GO:0030246 [carbohydrate binding] GO:0070062 [extracellular exosome] Show all	166 aa 18.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.