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FN1

GENERAL INFORMATION

Gene name

 FN1

Gene description

 Fibronectin 1

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (ASC TERT1)
HPA (normal tissue):Tissue enhanced (placenta)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Positivity in extracellular matrix and stromal cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 2 antibodies.
HPA027066 , CAB000126
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), stomach cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001
Stomach cancer p<0.001
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027066
CAB000126

GENE INFORMATION

Gene name

 FN1 (HGNC Symbol)

Synonyms

 CIG, FINC, GFND2, LETS, MSF

Description

 Fibronectin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 215360440 - 215436172

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115414 (version 83.38)

Entrez gene

 2335

UniProt

 P02751 (UniProt - Evidence at protein level)

neXtProt

 NX_P02751

Antibodypedia

 FN1 antibodies

PROTEIN BROWSER
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FN1-001
FN1-002
FN1-003
FN1-004
FN1-005
FN1-008
FN1-009
FN1-011
FN1-012
FN1-013
FN1-014
FN1-026
FN1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FN1-001
ENSP00000346839
ENST00000354785
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001775 [cell activation]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0002931 [response to ischemia]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005604 [basement membrane]
GO:0005605 [basal lamina]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008347 [glial cell migration]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010193 [response to ozone]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0016324 [apical plasma membrane]
GO:0016504 [peptidase activator activity]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030335 [positive regulation of cell migration]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0035987 [endodermal cell differentiation]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0042060 [wound healing]
GO:0043066 [negative regulation of apoptotic process]
GO:0045340 [mercury ion binding]
GO:0045773 [positive regulation of axon extension]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0050921 [positive regulation of chemotaxis]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071288 [cellular response to mercury ion]
GO:0071333 [cellular response to glucose stimulus]
GO:0071347 [cellular response to interleukin-1]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0071773 [cellular response to BMP stimulus]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
 2477 aa
272.3 kDa 		Yes 0
FN1-002
ENSP00000323534
ENST00000323926
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
 2446 aa
268.9 kDa 		Yes 0
FN1-003
ENSP00000338200
ENST00000336916
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
 2355 aa
259.2 kDa 		Yes 0
FN1-004
ENSP00000350534
ENST00000357867
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
 2176 aa
239.6 kDa 		Yes 0
FN1-005
ENSP00000394423
ENST00000421182
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
 2240 aa
246.7 kDa 		Yes 0
FN1-008
ENSP00000410422
ENST00000446046
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
 2330 aa
256.5 kDa 		Yes 0
FN1-009
ENSP00000415018
ENST00000443816
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
 2265 aa
249.4 kDa 		Yes 0
FN1-011
ENSP00000416139
ENST00000456923
H0Y7Z1 [Direct mapping]
Fibronectin
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
Show all
 1103 aa
120.8 kDa 		No 0
FN1-012
ENSP00000399538
ENST00000432072
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
 2267 aa
249.3 kDa 		Yes 0
FN1-013
ENSP00000348285
ENST00000356005
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
 2296 aa
252.8 kDa 		Yes 0
FN1-014
ENSP00000398907
ENST00000426059
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
 657 aa
73.7 kDa 		Yes 0
FN1-026
ENSP00000392565
ENST00000438981
H0Y4K8 [Direct mapping]
Fibronectin
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 241 aa
26.6 kDa 		No 0
FN1-201
ENSP00000352696
ENST00000359671
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
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GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
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 2386 aa
262.6 kDa 		Yes 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.