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PAPOLG

GENERAL INFORMATION

Gene name

 PAPOLG

Gene description

 Poly(A) polymerase gamma

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB017795
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB017795

GENE INFORMATION

Gene name

 PAPOLG (HGNC Symbol)

Synonyms

 FLJ12972

Description

 Poly(A) polymerase gamma (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p16.1

Chromosome location (bp)

 60756230 - 60802085

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115421 (version 83.38)

Entrez gene

 64895

UniProt

 Q9BWT3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BWT3

Antibodypedia

 PAPOLG antibodies

PROTEIN BROWSER
PAPOLG-001
PAPOLG-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAPOLG-001
ENSP00000238714
ENST00000238714
Q9BWT3 [Direct mapping]
Poly(A) polymerase gamma
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0004652 [polynucleotide adenylyltransferase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006378 [mRNA polyadenylation]
GO:0016020 [membrane]
GO:0016779 [nucleotidyltransferase activity]
GO:0031123 [RNA 3'-end processing]
GO:0043631 [RNA polyadenylation]
GO:0046872 [metal ion binding]
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 736 aa
82.8 kDa 		No 1
PAPOLG-005
ENSP00000405570
ENST00000412217
A0A0C4DH56 [Direct mapping]
Poly(A) polymerase gamma
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0004652 [polynucleotide adenylyltransferase activity]
GO:0005634 [nucleus]
GO:0006378 [mRNA polyadenylation]
GO:0016779 [nucleotidyltransferase activity]
GO:0031123 [RNA 3'-end processing]
GO:0043631 [RNA polyadenylation]
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 382 aa
42.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.