We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
IGFBP5
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

IGFBP5

Gene description

Insulin-like growth factor binding protein 5

Protein class

Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ, BJ hTERT+, T-47d, U-138 MG)
HPA (normal tissue):Tissue enhanced (cervix, uterine, ovary)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly expression of neuronal processes in CNS and extracellular expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External data supports expression in CNS.

Reliability score

Approved based on 1 antibody.
CAB009216
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB009216

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Carcinoid, colorectal, prostate and breast cancers showed moderate cytoplasmic positivity in most cases. Most remaining cancer tissues displayed weak cytoplasmic staining.

GENE INFORMATION

Gene name

IGFBP5

Synonyms

Description

Insulin-like growth factor binding protein 5 (HGNC Symbol)

Entrez gene summary

Chromosome

2

Cytoband

q35

Chromosome location (bp)

216672105 - 216695525

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115461 (version 83.38)

Entrez gene

3488

UniProt

P24593 (UniProt - Evidence at protein level)

neXtProt

NX_P24593

Antibodypedia

IGFBP5 antibodies

PROTEIN BROWSER

IGFBP5-001
IGFBP5-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IGFBP5-001
ENSP00000233813
ENST00000233813
P24593 [Direct mapping]
Insulin-like growth factor-binding protein 5
A0A024R433 [Target identity:100%; Query identity:100%]
Insulin-like growth factor binding protein 5, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001649 [osteoblast differentiation]
GO:0001968 [fibronectin binding]
GO:0005515 [protein binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006006 [glucose metabolic process]
GO:0007165 [signal transduction]
GO:0007565 [female pregnancy]
GO:0010906 [regulation of glucose metabolic process]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0016942 [insulin-like growth factor binding protein complex]
GO:0017148 [negative regulation of translation]
GO:0030336 [negative regulation of cell migration]
GO:0031069 [hair follicle morphogenesis]
GO:0031994 [insulin-like growth factor I binding]
GO:0031995 [insulin-like growth factor II binding]
GO:0035556 [intracellular signal transduction]
GO:0040008 [regulation of growth]
GO:0042567 [insulin-like growth factor ternary complex]
GO:0042593 [glucose homeostasis]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0043569 [negative regulation of insulin-like growth factor receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0044342 [type B pancreatic cell proliferation]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045926 [negative regulation of growth]
GO:0048286 [lung alveolus development]
GO:0048630 [skeletal muscle tissue growth]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0051146 [striated muscle cell differentiation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060056 [mammary gland involution]
GO:0060416 [response to growth hormone]
GO:0071320 [cellular response to cAMP]
GO:0071407 [cellular response to organic cyclic compound]
GO:1901862 [negative regulation of muscle tissue development]
GO:1904205 [negative regulation of skeletal muscle hypertrophy]
Show all
272 aa
30.6 kDa
Yes 0
IGFBP5-003
ENSP00000413474
ENST00000449583
C9JXX4 [Direct mapping]
Insulin-like growth factor-binding protein 5
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001968 [fibronectin binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0031995 [insulin-like growth factor II binding]
Show all
233 aa
25.5 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.