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CCT4

GENERAL INFORMATION

Gene name

 CCT4

Gene description

 Chaperonin containing TCP1, subunit 4 (delta)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic positivity in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 1 antibody.
HPA029349
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and breast cancer (unfavourable).
Liver cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029349

GENE INFORMATION

Gene name

 CCT4 (HGNC Symbol)

Synonyms

 Cctd

Description

 Chaperonin containing TCP1, subunit 4 (delta) (HGNC Symbol)

Entrez gene summary

 The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 p15

Chromosome location (bp)

 61868089 - 61888804

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115484 (version 83.38)

Entrez gene

 10575

UniProt

 P50991 (UniProt - Evidence at protein level)

neXtProt

 NX_P50991

Antibodypedia

 CCT4 antibodies

PROTEIN BROWSER
CCT4-001
CCT4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCT4-001
ENSP00000377958
ENST00000394440
P50991 [Direct mapping]
T-complex protein 1 subunit delta
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002199 [zona pellucida receptor complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005832 [chaperonin-containing T-complex]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007339 [binding of sperm to zona pellucida]
GO:0042470 [melanosome]
GO:0044267 [cellular protein metabolic process]
GO:0044297 [cell body]
GO:0044822 [poly(A) RNA binding]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0070062 [extracellular exosome]
GO:1901998 [toxin transport]
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 539 aa
57.9 kDa 		No 0
CCT4-201
ENSP00000443061
ENST00000544079
P50991 [Direct mapping]
T-complex protein 1 subunit delta
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005832 [chaperonin-containing T-complex]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0042470 [melanosome]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0070062 [extracellular exosome]
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 509 aa
54.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.