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A rare case of melanoma and colorectal cancer showed moderate cytoplasmic and nuclear positivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
NEU2 (HGNC Symbol)
Synonyms
SIAL2
Description
Sialidase 2 (cytosolic sialidase) (HGNC Symbol)
Entrez gene summary
This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. [provided by RefSeq, Jul 2008]