Cancer tissues showed moderate to strong cytoplasmic positivity, and a few cases with additional membranous positivity. Several lymphomas, renal cancers and hepatocellular carcinomas were weakly stained or negative.
Most cancer cells showed weak to moderate cytoplasmic and membranous immunoreactivity. A few cases of melanomas and gliomas were strongly stained. Most cases of lymphomas and endometrial cancers were negative.
EHBP1 (HGNC Symbol)
EH domain binding protein 1 (HGNC Symbol)
Entrez gene summary
This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]