Expression of EHBP1 in cancer - Summary - The Human Protein Atlas

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EHBP1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EHBP1
Gene description	EH domain binding protein 1
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA035468 , HPA035469
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable) and lung cancer (unfavourable).
Urothelial cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035468	HPA035469

GENE INFORMATION
Gene name	EHBP1 (HGNC Symbol)
Synonyms	KIAA0903, NACSIN
Description	EH domain binding protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Chromosome	2
Cytoband	p15
Chromosome location (bp)	62673851 - 63046487
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115504 (version 83.38)
Entrez gene	23301
UniProt	Q8NDI1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NDI1
Antibodypedia	EHBP1 antibodies

PROTEIN BROWSER

EHBP1-001	EHBP1-002	EHBP1-003	EHBP1-005	EHBP1-007	EHBP1-010	EHBP1-011	EHBP1-013	EHBP1-014	EHBP1-015	EHBP1-016	EHBP1-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EHBP1-001 ENSP00000263991 ENST00000263991	Q8NDI1 [Direct mapping] EH domain-binding protein 1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	1231 aa 140 kDa	No	0
EHBP1-002 ENSP00000384143 ENST00000405015	Q8NDI1 [Direct mapping] EH domain-binding protein 1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	1160 aa 132.3 kDa	No	0
EHBP1-003 ENSP00000403783 ENST00000431489	Q8NDI1 [Direct mapping] EH domain-binding protein 1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	1160 aa 132.3 kDa	No	0
EHBP1-005 ENSP00000384829 ENST00000405482	B5MC86 [Direct mapping] EH domain-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	310 aa 35.5 kDa	No	0
EHBP1-007 ENSP00000385524 ENST00000405289	Q8NDI1 [Direct mapping] EH domain-binding protein 1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	1196 aa 136.2 kDa	No	0
EHBP1-010 ENSP00000392441 ENST00000426940	C9J268 [Direct mapping] EH domain-binding protein 1 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		41 aa 4.7 kDa	No	0
EHBP1-011 ENSP00000404617 ENST00000427809	C9JEP1 [Direct mapping] EH domain-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		77 aa 9.1 kDa	No	0
EHBP1-013 ENSP00000399609 ENST00000449820	C9K0H9 [Direct mapping] EH domain-binding protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		95 aa 10.7 kDa	Yes	0
EHBP1-014 ENSP00000392192 ENST00000413434	C9IYU2 [Direct mapping] EH domain-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		108 aa 12.6 kDa	No	0
EHBP1-015 ENSP00000396186 ENST00000454124	H7C0Q4 [Direct mapping] EH domain-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 12.5 kDa	No	0
EHBP1-016 ENSP00000399927 ENST00000444311	H7C1E6 [Direct mapping] EH domain-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		154 aa 17.4 kDa	No	0
EHBP1-017 ENSP00000388442 ENST00000422032	H7BZ98 [Direct mapping] EH domain-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		223 aa 25.2 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.