Expression of CHST10 in cancer - Summary - The Human Protein Atlas

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CHST10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CHST10
Gene description	Carbohydrate sulfotransferase 10
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA012884
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012884

GENE INFORMATION
Gene name	CHST10 (HGNC Symbol)
Synonyms	HNK-1ST
Description	Carbohydrate sulfotransferase 10 (HGNC Symbol)
Entrez gene summary	This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011]
Chromosome	2
Cytoband	q11.2
Chromosome location (bp)	100391860 - 100417656
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115526 (version 83.38)
Entrez gene	9486
UniProt	O43529 (UniProt - Evidence at protein level)
neXtProt	NX_O43529
Antibodypedia	CHST10 antibodies

PROTEIN BROWSER

CHST10-001	CHST10-002	CHST10-003	CHST10-004	CHST10-005	CHST10-006	CHST10-007	CHST10-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHST10-001 ENSP00000264249 ENST00000264249	O43529 [Direct mapping] Carbohydrate sulfotransferase 10 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0000139 [Golgi membrane] GO:0005794 [Golgi apparatus] GO:0007155 [cell adhesion] GO:0007612 [learning] GO:0007616 [long-term memory] GO:0008146 [sulfotransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] GO:0016232 [HNK-1 sulfotransferase activity] Show all	356 aa 42.2 kDa	Yes	0
CHST10-002 ENSP00000387309 ENST00000409701	O43529 [Direct mapping] Carbohydrate sulfotransferase 10 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0000139 [Golgi membrane] GO:0005794 [Golgi apparatus] GO:0007155 [cell adhesion] GO:0008146 [sulfotransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] Show all	356 aa 42.2 kDa	Yes	0
CHST10-003 ENSP00000416831 ENST00000418201	C9JCK7 [Direct mapping] Carbohydrate sulfotransferase 10 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] Show all	64 aa 7.7 kDa	No	0
CHST10-004 ENSP00000405922 ENST00000420858	C9J5X0 [Direct mapping] Carbohydrate sulfotransferase 10 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] Show all	133 aa 15.6 kDa	Yes	0
CHST10-005 ENSP00000387121 ENST00000409046	B8ZZ48 [Direct mapping] Carbohydrate sulfotransferase 10 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] Show all	141 aa 16.6 kDa	Yes	0
CHST10-006 ENSP00000387977 ENST00000448989	C9JWY0 [Direct mapping] Carbohydrate sulfotransferase 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] Show all	142 aa 16.9 kDa	No	1
CHST10-007 ENSP00000395643 ENST00000435960	C9JI33 [Direct mapping] Carbohydrate sulfotransferase 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] Show all	33 aa 4 kDa	No	1
CHST10-010 ENSP00000407525 ENST00000421474	C9JUE4 [Direct mapping] Carbohydrate sulfotransferase 10 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0016051 [carbohydrate biosynthetic process] Show all	85 aa 10.1 kDa	Yes	0

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