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PDCL3

GENERAL INFORMATION

Gene name

 PDCL3

Gene description

 Phosducin-like 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA018469 , HPA027094
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA018469
HPA027094

GENE INFORMATION

Gene name

 PDCL3 (HGNC Symbol)

Synonyms

 VIAF1

Description

 Phosducin-like 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q11.2

Chromosome location (bp)

 100562690 - 100576735

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115539 (version 83.38)

Entrez gene

 79031

UniProt

 Q9H2J4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H2J4

Antibodypedia

 PDCL3 antibodies

PROTEIN BROWSER
PDCL3-001
PDCL3-002
PDCL3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDCL3-001
ENSP00000264254
ENST00000264254
Q9H2J4 [Direct mapping]
Phosducin-like protein 3
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001525 [angiogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006457 [protein folding]
GO:0006915 [apoptotic process]
GO:0016032 [viral process]
GO:0043184 [vascular endothelial growth factor receptor 2 binding]
GO:0044183 [protein binding involved in protein folding]
GO:0045766 [positive regulation of angiogenesis]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:2000059 [negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
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 239 aa
27.6 kDa 		No 0
PDCL3-002
ENSP00000390585
ENST00000450127
H7BZP2 [Direct mapping]
Phosducin-like protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 150 aa
17 kDa 		No 0
PDCL3-003
ENSP00000413936
ENST00000416255
C9JST4 [Direct mapping]
Phosducin-like protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 87 aa
10.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.