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MOB4

GENERAL INFORMATION

Gene name

 MOB4

Gene description

 MOB family member 4, phocein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 2 antibodies.
HPA044125 , CAB034082
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044125
CAB034082

GENE INFORMATION

Gene name

 MOB4 (HGNC Symbol)

Synonyms

 2C4D, CGI-95, DKFZP564M112, MOB3, MOBKL3, PHOCN, PREI3

Description

 MOB family member 4, phocein (HGNC Symbol)

Entrez gene summary

 This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.[provided by RefSeq, Feb 2011]

Chromosome

 2

Cytoband

 q33.1

Chromosome location (bp)

 197515571 - 197553699

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115540 (version 83.38)

Entrez gene

 25843

UniProt

 Q9Y3A3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y3A3

Antibodypedia

 MOB4 antibodies

PROTEIN BROWSER
MOB4-001
MOB4-002
MOB4-005
MOB4-006
MOB4-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MOB4-001
ENSP00000315702
ENST00000323303
Q9Y3A3 [Direct mapping]
MOB-like protein phocein
A0A024R3X9 [Target identity:100%; Query identity:100%]
Preimplantation protein 3, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0019900 [kinase binding]
GO:0032580 [Golgi cisterna membrane]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
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 225 aa
26 kDa 		No 0
MOB4-002
ENSP00000233892
ENST00000233892
Q9Y3A3 [Direct mapping]
MOB-like protein phocein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0032580 [Golgi cisterna membrane]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
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 193 aa
22.3 kDa 		No 0
MOB4-005
ENSP00000387240
ENST00000409916
B4DM50 [Direct mapping]
MOB-like protein phocein; cDNA FLJ52887, highly similar to Preimplantation protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 126 aa
14.6 kDa 		No 0
MOB4-006
ENSP00000405354
ENST00000448447
Q9Y3A3 [Direct mapping]
MOB-like protein phocein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0032580 [Golgi cisterna membrane]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
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 204 aa
23.5 kDa 		No 0
MOB4-008
ENSP00000387289
ENST00000409360
Q9Y3A3 [Direct mapping]
MOB-like protein phocein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006810 [transport]
GO:0032580 [Golgi cisterna membrane]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 193 aa
22.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.