Expression of IL1R2 in cancer - Summary - The Human Protein Atlas

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IL1R2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IL1R2
Gene description	Interleukin 1 receptor, type II
Protein class	Cancer-related genes CD markers Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (HDLM-2)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 2 antibodies. HPA027597 , HPA027598
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027597	HPA027598

GENE INFORMATION
Gene name	IL1R2 (HGNC Symbol)
Synonyms	CD121b, IL1RB
Description	Interleukin 1 receptor, type II (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
Chromosome	2
Cytoband	q11.2
Chromosome location (bp)	101991844 - 102028544
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115590 (version 83.38)
Entrez gene	7850
UniProt	P27930 (UniProt - Evidence at protein level)
neXtProt	NX_P27930
Antibodypedia	IL1R2 antibodies

PROTEIN BROWSER

IL1R2-001	IL1R2-002	IL1R2-003	IL1R2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL1R2-001 ENSP00000330959 ENST00000332549	P27930 [Direct mapping] Interleukin-1 receptor type 2 Interleukin-1 receptor type 2, membrane form Interleukin-1 receptor type 2, soluble form Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004908 [interleukin-1 receptor activity] GO:0004910 [interleukin-1, Type II, blocking receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	398 aa 45.4 kDa	Yes	1
IL1R2-002 ENSP00000377066 ENST00000393414	P27930 [Direct mapping] Interleukin-1 receptor type 2 Interleukin-1 receptor type 2, membrane form Interleukin-1 receptor type 2, soluble form Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004908 [interleukin-1 receptor activity] GO:0004910 [interleukin-1, Type II, blocking receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	398 aa 45.4 kDa	Yes	1
IL1R2-003 ENSP00000414611 ENST00000441002	P27930 [Direct mapping] Interleukin-1 receptor type 2 Interleukin-1 receptor type 2, membrane form Interleukin-1 receptor type 2, soluble form Show all	CD markers MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004908 [interleukin-1 receptor activity] GO:0004910 [interleukin-1, Type II, blocking receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	296 aa 33.6 kDa	Yes	0
IL1R2-005 ENSP00000408415 ENST00000457817	C9JNR0 [Direct mapping] Interleukin-1 receptor type 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004910 [interleukin-1, Type II, blocking receptor activity] GO:0005515 [protein binding] GO:0019221 [cytokine-mediated signaling pathway] Show all	229 aa 26.3 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.