Expression of IL1R1 in cancer - Summary - The Human Protein Atlas

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IL1R1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IL1R1
Gene description	Interleukin 1 receptor, type I
Protein class	Cancer-related genes CD markers FDA approved drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, BJ hTERT+, U-2197)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Positivity in plasma in several tissues. Membranous expression in small intestines.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 3 antibodies. HPA005823 , HPA029560 , CAB007779
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA005823	HPA029560	CAB007779

GENE INFORMATION
Gene name	IL1R1 (HGNC Symbol)
Synonyms	CD121A, D2S1473, IL1R, IL1RA
Description	Interleukin 1 receptor, type I (HGNC Symbol)
Entrez gene summary	This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
Chromosome	2
Cytoband
Chromosome location (bp)	102064544 - 102179874
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115594 (version 83.38)
Entrez gene	3554
UniProt	P14778 (UniProt - Evidence at protein level)
neXtProt	NX_P14778
Antibodypedia	IL1R1 antibodies

PROTEIN BROWSER

IL1R1-001	IL1R1-002	IL1R1-003	IL1R1-004	IL1R1-005	IL1R1-006	IL1R1-007	IL1R1-010	IL1R1-011	IL1R1-012	IL1R1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL1R1-001 ENSP00000386380 ENST00000410023	P14778 [Direct mapping] Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0004871 [signal transducer activity] GO:0004888 [transmembrane signaling receptor activity] GO:0004908 [interleukin-1 receptor activity] GO:0004909 [interleukin-1, Type I, activating receptor activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0009314 [response to radiation] GO:0009986 [cell surface] GO:0010286 [heat acclimation] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030424 [axon] GO:0030728 [ovulation] GO:0035255 [ionotropic glutamate receptor binding] GO:0043234 [protein complex] GO:0050727 [regulation of inflammatory response] GO:0070498 [interleukin-1-mediated signaling pathway] GO:0070555 [response to interleukin-1] GO:0070849 [response to epidermal growth factor] GO:0071333 [cellular response to glucose stimulus] GO:0071559 [response to transforming growth factor beta] GO:0071731 [response to nitric oxide] Show all	569 aa 65.4 kDa	Yes	1
IL1R1-002 ENSP00000386478 ENST00000409288	B8ZZ73 [Direct mapping] Interleukin-1 receptor type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004909 [interleukin-1, Type I, activating receptor activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0070498 [interleukin-1-mediated signaling pathway] Show all	447 aa 51.3 kDa	Yes	1
IL1R1-003 ENSP00000410461 ENST00000428279	C9J3W8 [Direct mapping] Interleukin-1 receptor type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004909 [interleukin-1, Type I, activating receptor activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0070498 [interleukin-1-mediated signaling pathway] Show all	298 aa 34.4 kDa	No	1
IL1R1-004 ENSP00000387131 ENST00000409329	B8ZZ73 [Direct mapping] Interleukin-1 receptor type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004909 [interleukin-1, Type I, activating receptor activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0070498 [interleukin-1-mediated signaling pathway] Show all	447 aa 51.3 kDa	Yes	1
IL1R1-005 ENSP00000386555 ENST00000409589	B9A040 [Direct mapping] Interleukin-1 receptor type 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004909 [interleukin-1, Type I, activating receptor activity] GO:0005515 [protein binding] GO:0070498 [interleukin-1-mediated signaling pathway] Show all	173 aa 19.9 kDa	Yes	0
IL1R1-006 ENSP00000386776 ENST00000409929	B8ZZW4 [Direct mapping] Interleukin-1 receptor type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004909 [interleukin-1, Type I, activating receptor activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0070498 [interleukin-1-mediated signaling pathway] Show all	538 aa 62 kDa	Yes	1
IL1R1-007 ENSP00000408101 ENST00000430171	C9JQ36 [Direct mapping] Interleukin-1 receptor type 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004909 [interleukin-1, Type I, activating receptor activity] GO:0005515 [protein binding] GO:0070498 [interleukin-1-mediated signaling pathway] Show all	182 aa 21 kDa	Yes	0
IL1R1-010 ENSP00000393296 ENST00000442590	C9JWB2 [Direct mapping] Interleukin-1 receptor type 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004909 [interleukin-1, Type I, activating receptor activity] GO:0005515 [protein binding] GO:0070498 [interleukin-1-mediated signaling pathway] Show all	114 aa 13.1 kDa	Yes	0
IL1R1-011 ENSP00000411627 ENST00000450319	C9J686 [Direct mapping] Interleukin-1 receptor type 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004909 [interleukin-1, Type I, activating receptor activity] GO:0005515 [protein binding] GO:0070498 [interleukin-1-mediated signaling pathway] Show all	106 aa 12.3 kDa	Yes	0
IL1R1-012 ENSP00000401646 ENST00000452403	C9JW84 [Direct mapping] Interleukin-1 receptor type 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004909 [interleukin-1, Type I, activating receptor activity] GO:0070498 [interleukin-1-mediated signaling pathway] Show all	80 aa 9.2 kDa	Yes	0
IL1R1-013 ENSP00000415366 ENST00000424272	B8ZZ73 [Direct mapping] Interleukin-1 receptor type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004909 [interleukin-1, Type I, activating receptor activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0070498 [interleukin-1-mediated signaling pathway] Show all	447 aa 51.3 kDa	Yes	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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