Expression of IL18R1 in cancer - Summary - The Human Protein Atlas

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IL18R1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IL18R1
Gene description	Interleukin 18 receptor 1
Protein class	CD markers Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HDLM-2, HMC-1, U-937)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with a granular pattern, including immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA007615
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007615

GENE INFORMATION
Gene name	IL18R1 (HGNC Symbol)
Synonyms	CD218a, IL-1Rrp, IL1RRP
Description	Interleukin 18 receptor 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Chromosome	2
Cytoband	q12.1
Chromosome location (bp)	102311529 - 102398775
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115604 (version 83.38)
Entrez gene	8809
UniProt	Q13478 (UniProt - Evidence at protein level)
neXtProt	NX_Q13478
Antibodypedia	IL18R1 antibodies

PROTEIN BROWSER

IL18R1-001	IL18R1-003	IL18R1-201	IL18R1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL18R1-001 ENSP00000387211 ENST00000409599	Q13478 [Direct mapping] Interleukin-18 receptor 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0004908 [interleukin-1 receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0030101 [natural killer cell activation] GO:0032729 [positive regulation of interferon-gamma production] GO:0035655 [interleukin-18-mediated signaling pathway] GO:0042008 [interleukin-18 receptor activity] GO:0042346 [positive regulation of NF-kappaB import into nucleus] GO:0045063 [T-helper 1 cell differentiation] Show all	541 aa 62.3 kDa	Yes	1
IL18R1-003 ENSP00000386663 ENST00000410040	Q13478 [Direct mapping] Interleukin-18 receptor 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0004908 [interleukin-1 receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] Show all	541 aa 62.3 kDa	Yes	1
IL18R1-201 ENSP00000233957 ENST00000233957	Q13478 [Direct mapping] Interleukin-18 receptor 1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0004908 [interleukin-1 receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] Show all	541 aa 62.3 kDa	Yes	1
IL18R1-202 ENSP00000334030 ENST00000334376	Q86YL8 [Direct mapping] Interleukin-18 receptor 1; Putative soluble interleukin 18 receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	170 aa 19.7 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.