Expression of SLC9A2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SLC9A2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC9A2
Gene description	Solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
Protein class	Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A-431, RT4, SK-BR-3, T-47d)
HPA (normal tissue):	Tissue enhanced (colon, rectum, stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA035121 , HPA035122
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035121	HPA035122

GENE INFORMATION
Gene name	SLC9A2 (HGNC Symbol)
Synonyms	NHE2
Description	Solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q12.1
Chromosome location (bp)	102619707 - 102711318
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115616 (version 83.38)
Entrez gene	6549
UniProt	Q9UBY0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UBY0
Antibodypedia	SLC9A2 antibodies

PROTEIN BROWSER

SLC9A2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC9A2-001 ENSP00000233969 ENST00000233969	Q9UBY0 [Direct mapping] Sodium/hydrogen exchanger 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0006885 [regulation of pH] GO:0008104 [protein localization] GO:0015299 [solute:proton antiporter activity] GO:0015385 [sodium:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	812 aa 91.5 kDa	Yes	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.