Expression of CNPPD1 in cancer - Summary - The Human Protein Atlas

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CNPPD1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CNPPD1
Gene description	Cyclin Pas1/PHO80 domain containing 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic and membrane expression in several tissues

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA049303
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049303

GENE INFORMATION
Gene name	CNPPD1 (HGNC Symbol)
Synonyms	C2orf24, CGI-57
Description	Cyclin Pas1/PHO80 domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q35
Chromosome location (bp)	219171897 - 219178106
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000115649 (version 83.38)
Entrez gene	27013
UniProt	Q9BV87 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BV87
Antibodypedia	CNPPD1 antibodies

PROTEIN BROWSER

CNPPD1-001	CNPPD1-003	CNPPD1-004	CNPPD1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNPPD1-001 ENSP00000353698 ENST00000360507	Q9BV87 [Direct mapping] Protein CNPPD1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0016021 [integral component of membrane] GO:0019901 [protein kinase binding] Show all	410 aa 45.5 kDa	No	1
CNPPD1-003 ENSP00000386277 ENST00000409789	Q9BV87 [Direct mapping] Protein CNPPD1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0016021 [integral component of membrane] GO:0019901 [protein kinase binding] Show all	410 aa 45.5 kDa	No	1
CNPPD1-004 ENSP00000410109 ENST00000453038	C9JF31 [Direct mapping] Protein CNPPD1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0019901 [protein kinase binding] Show all	308 aa 34.2 kDa	No	1
CNPPD1-005 ENSP00000405997 ENST00000451647	C9J597 [Direct mapping] Protein CNPPD1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	283 aa 31.8 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.