Expression of HDLBP in cancer - Summary

GENERAL INFORMATION
Gene name	HDLBP
Gene description	High density lipoprotein binding protein
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	27
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression at variable levels in most tissues. Highly abundant in exocrine pancreas and placenta.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA004189 , CAB026457
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), thyroid cancer (unfavourable) and urothelial cancer (unfavourable).
Liver cancer p<0.001 Thyroid cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA004189	CAB026457

GENE INFORMATION
Gene name	HDLBP (HGNC Symbol)
Synonyms	HBP, VGL
Description	High density lipoprotein binding protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Chromosome	2
Cytoband	q37.3
Chromosome location (bp)	241227264 - 241317061
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115677 (version 83.38)
Entrez gene	3069
UniProt	Q00341 (UniProt - Evidence at protein level)
neXtProt	NX_Q00341
Antibodypedia	HDLBP antibodies

PROTEIN BROWSER

HDLBP-001	HDLBP-002	HDLBP-003	HDLBP-004	HDLBP-006	HDLBP-009	HDLBP-011	HDLBP-012	HDLBP-013	HDLBP-015	HDLBP-016	HDLBP-019	HDLBP-020	HDLBP-021	HDLBP-022	HDLBP-024	HDLBP-025	HDLBP-027	HDLBP-028	HDLBP-029	HDLBP-030	HDLBP-031	HDLBP-033	HDLBP-042	HDLBP-044	HDLBP-062	HDLBP-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HDLBP-001 ENSP00000375836 ENST00000391975	A0A024R4E5 [Direct mapping] High density lipoprotein binding protein (Vigilin), isoform CRA_a; Vigilin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	1268 aa 141.4 kDa	No	0
HDLBP-002 ENSP00000375837 ENST00000391976	A0A024R4E5 [Direct mapping] High density lipoprotein binding protein (Vigilin), isoform CRA_a; Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	1268 aa 141.4 kDa	No	0
HDLBP-003 ENSP00000312042 ENST00000310931	A0A024R4E5 [Direct mapping] High density lipoprotein binding protein (Vigilin), isoform CRA_a; Vigilin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	1268 aa 141.4 kDa	No	0
HDLBP-004 ENSP00000362389 ENST00000373292	H0Y394 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	973 aa 108.7 kDa	No	0
HDLBP-006 ENSP00000390942 ENST00000425989	C9JEJ8 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		79 aa 8.5 kDa	No	0
HDLBP-009 ENSP00000391773 ENST00000417540	C9JB08 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		14 aa 1.5 kDa	No	0
HDLBP-011 ENSP00000396964 ENST00000441124	C9JHS7 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		126 aa 13.9 kDa	No	0
HDLBP-012 ENSP00000390290 ENST00000413241	C9JHN6 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		82 aa 8.9 kDa	No	0
HDLBP-013 ENSP00000413805 ENST00000423693	A0A0E3D6N3 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		81 aa 8.8 kDa	No	0
HDLBP-015 ENSP00000405109 ENST00000428482	C9J5E5 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005737 [cytoplasm] Show all	221 aa 24.4 kDa	No	0
HDLBP-016 ENSP00000403693 ENST00000420451	C9JBS3 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 7.5 kDa	No	0
HDLBP-019 ENSP00000403913 ENST00000430918	C9JHZ8 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		141 aa 15.5 kDa	No	0
HDLBP-020 ENSP00000413891 ENST00000442714	C9JK79 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		128 aa 14.3 kDa	No	0
HDLBP-021 ENSP00000396202 ENST00000449864	C9JE93 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		36 aa 4.1 kDa	No	0
HDLBP-022 ENSP00000396959 ENST00000449504	C9JHS9 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		17 aa 1.9 kDa	No	0
HDLBP-024 ENSP00000394205 ENST00000426343	C9JT62 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		96 aa 10.6 kDa	No	0
HDLBP-025 ENSP00000416559 ENST00000444092	C9JES8 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		147 aa 16.2 kDa	No	0
HDLBP-027 ENSP00000387782 ENST00000452065	C9JZI8 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		164 aa 18.1 kDa	No	0
HDLBP-028 ENSP00000397799 ENST00000427007	C9J739 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		19 aa 2 kDa	No	0
HDLBP-029 ENSP00000409868 ENST00000422080	C9JQ82 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		54 aa 5.9 kDa	No	0
HDLBP-030 ENSP00000408582 ENST00000458564	C9JMQ6 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		47 aa 5.1 kDa	No	0
HDLBP-031 ENSP00000403807 ENST00000422933	C9JIZ1 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005737 [cytoplasm] Show all	224 aa 24.7 kDa	No	0
HDLBP-033 ENSP00000393766 ENST00000453141	H7C0A4 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	333 aa 37 kDa	No	0
HDLBP-042 ENSP00000388876 ENST00000452931	H7BZC3 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	267 aa 29.8 kDa	No	0
HDLBP-044 ENSP00000405180 ENST00000427487	H7C2D1 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	308 aa 34.2 kDa	No	0
HDLBP-062 ENSP00000411211 ENST00000442730	H7C3D0 [Direct mapping] Vigilin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	126 aa 13.7 kDa	No	0
HDLBP-201 ENSP00000399139 ENST00000427183	Q00341 [Direct mapping] Vigilin Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006869 [lipid transport] GO:0008203 [cholesterol metabolic process] GO:0008289 [lipid binding] GO:0034364 [high-density lipoprotein particle] GO:0044822 [poly(A) RNA binding] Show all	1235 aa 138 kDa	No	0