Expression of PASK in cancer - Summary - The Human Protein Atlas

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PASK

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PASK
Gene description	PAS domain containing serine/threonine kinase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA016450 , HPA021079
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016450	HPA021079

GENE INFORMATION
Gene name	PASK (HGNC Symbol)
Synonyms	KIAA0135, PASKIN, STK37
Description	PAS domain containing serine/threonine kinase (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Chromosome	2
Cytoband	q37.3
Chromosome location (bp)	241106099 - 241150264
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115687 (version 83.38)
Entrez gene	23178
UniProt	Q96RG2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96RG2
Antibodypedia	PASK antibodies

PROTEIN BROWSER

PASK-001	PASK-002	PASK-003	PASK-004	PASK-008	PASK-010	PASK-012	PASK-201	PASK-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PASK-001 ENSP00000234040 ENST00000234040	Q96RG2 [Direct mapping] PAS domain-containing serine/threonine-protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006468 [protein phosphorylation] GO:0035091 [phosphatidylinositol binding] GO:0043576 [regulation of respiratory gaseous exchange] GO:0045719 [negative regulation of glycogen biosynthetic process] GO:0045727 [positive regulation of translation] GO:0046777 [protein autophosphorylation] GO:0070092 [regulation of glucagon secretion] GO:2000505 [regulation of energy homeostasis] Show all	1323 aa 142.9 kDa	No	0
PASK-002 ENSP00000384438 ENST00000403638	Q96RG2 [Direct mapping] PAS domain-containing serine/threonine-protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006468 [protein phosphorylation] GO:0035091 [phosphatidylinositol binding] GO:0043576 [regulation of respiratory gaseous exchange] GO:0045719 [negative regulation of glycogen biosynthetic process] GO:0045727 [positive regulation of translation] GO:0046777 [protein autophosphorylation] GO:0070092 [regulation of glucagon secretion] GO:2000505 [regulation of energy homeostasis] Show all	1143 aa 123 kDa	No	0
PASK-003 ENSP00000384016 ENST00000405260	Q96RG2 [Direct mapping] PAS domain-containing serine/threonine-protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006468 [protein phosphorylation] GO:0035091 [phosphatidylinositol binding] GO:0043576 [regulation of respiratory gaseous exchange] GO:0045719 [negative regulation of glycogen biosynthetic process] GO:0045727 [positive regulation of translation] GO:0046777 [protein autophosphorylation] GO:0070092 [regulation of glucagon secretion] GO:2000505 [regulation of energy homeostasis] Show all	1323 aa 142.9 kDa	No	0
PASK-004 ENSP00000351475 ENST00000358649	Q96RG2 [Direct mapping] PAS domain-containing serine/threonine-protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006468 [protein phosphorylation] GO:0035091 [phosphatidylinositol binding] GO:0043576 [regulation of respiratory gaseous exchange] GO:0045719 [negative regulation of glycogen biosynthetic process] GO:0045727 [positive regulation of translation] GO:0046777 [protein autophosphorylation] GO:0070092 [regulation of glucagon secretion] GO:2000505 [regulation of energy homeostasis] Show all	1330 aa 143.7 kDa	No	0
PASK-008 ENSP00000400734 ENST00000415234	C9J1Z3 [Direct mapping] PAS domain-containing serine/threonine-protein kinase Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		140 aa 15.2 kDa	No	0
PASK-010 ENSP00000397922 ENST00000452907	C9J4R3 [Direct mapping] PAS domain-containing serine/threonine-protein kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 13.3 kDa	No	0
PASK-012 ENSP00000395672 ENST00000433589	H7C0L7 [Direct mapping] PAS domain-containing serine/threonine-protein kinase Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		193 aa 20.9 kDa	No	0
PASK-201 ENSP00000441374 ENST00000544142	Q96RG2 [Direct mapping] PAS domain-containing serine/threonine-protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006468 [protein phosphorylation] GO:0035091 [phosphatidylinositol binding] GO:0043576 [regulation of respiratory gaseous exchange] GO:0045719 [negative regulation of glycogen biosynthetic process] GO:0045727 [positive regulation of translation] GO:0046777 [protein autophosphorylation] GO:0070092 [regulation of glucagon secretion] GO:2000505 [regulation of energy homeostasis] Show all	1323 aa 142.9 kDa	No	0
PASK-202 ENSP00000486149 ENST00000629419	F8WEB4 [Direct mapping] PAS domain-containing serine/threonine-protein kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		71 aa 7.6 kDa	No	0

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