Expression of TPO in cancer - Summary - The Human Protein Atlas

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TPO

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TPO
Gene description	Thyroid peroxidase
Protein class	Disease related genes Enzymes FDA approved drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (thyroid cancer)
HPA (cell line):	Cell line enhanced (Karpas-707, RPMI-8226)
HPA (normal tissue):	Tissue enriched (thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in thyroid glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA007987 , CAB009587
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007987	CAB009587

GENE INFORMATION
Gene name	TPO (HGNC Symbol)
Synonyms	TPX
Description	Thyroid peroxidase (HGNC Symbol)
Entrez gene summary	This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
Chromosome	2
Cytoband	p25.3
Chromosome location (bp)	1374223 - 1543711
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115705 (version 83.38)
Entrez gene	7173
UniProt	P07202 (UniProt - Evidence at protein level)
neXtProt	NX_P07202
Antibodypedia	TPO antibodies

PROTEIN BROWSER

TPO-001	TPO-002	TPO-004	TPO-005	TPO-006	TPO-007	TPO-010	TPO-012	TPO-201	TPO-202	TPO-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TPO-001 ENSP00000329869 ENST00000329066	P07202 [Direct mapping] Thyroid peroxidase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0004447 [iodide peroxidase activity] GO:0004601 [peroxidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006590 [thyroid hormone generation] GO:0006979 [response to oxidative stress] GO:0009986 [cell surface] GO:0020037 [heme binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0035162 [embryonic hemopoiesis] GO:0042446 [hormone biosynthetic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	933 aa 103 kDa	Yes	1
TPO-002 ENSP00000371636 ENST00000382201	P07202 [Direct mapping] Thyroid peroxidase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0004447 [iodide peroxidase activity] GO:0004601 [peroxidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006590 [thyroid hormone generation] GO:0006979 [response to oxidative stress] GO:0009986 [cell surface] GO:0020037 [heme binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0035162 [embryonic hemopoiesis] GO:0042446 [hormone biosynthetic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	876 aa 96.7 kDa	Yes	1
TPO-004 ENSP00000405788 ENST00000422464	H0Y6H4 [Direct mapping] Thyroid peroxidase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004447 [iodide peroxidase activity] GO:0004601 [peroxidase activity] GO:0006590 [thyroid hormone generation] GO:0006979 [response to oxidative stress] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	864 aa 95.2 kDa	No	1
TPO-005 ENSP00000371633 ENST00000382198	P07202 [Direct mapping] Thyroid peroxidase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0004447 [iodide peroxidase activity] GO:0004601 [peroxidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006590 [thyroid hormone generation] GO:0006979 [response to oxidative stress] GO:0009986 [cell surface] GO:0020037 [heme binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0035162 [embryonic hemopoiesis] GO:0042446 [hormone biosynthetic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	760 aa 84.6 kDa	Yes	1
TPO-006 ENSP00000371704 ENST00000382269	E9PFM6 [Direct mapping] Thyroid peroxidase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0004447 [iodide peroxidase activity] GO:0006590 [thyroid hormone generation] GO:0016021 [integral component of membrane] GO:0055114 [oxidation-reduction process] Show all	174 aa 19.3 kDa	Yes	0
TPO-007 ENSP00000400033 ENST00000446278	H7C1F5 [Direct mapping] Thyroid peroxidase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004447 [iodide peroxidase activity] GO:0004601 [peroxidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0006590 [thyroid hormone generation] GO:0006979 [response to oxidative stress] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	404 aa 45.1 kDa	No	1
TPO-010 ENSP00000390994 ENST00000423320	C9J511 [Direct mapping] Thyroid peroxidase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0004447 [iodide peroxidase activity] GO:0006590 [thyroid hormone generation] GO:0016021 [integral component of membrane] GO:0055114 [oxidation-reduction process] Show all	172 aa 19 kDa	Yes	0
TPO-012 ENSP00000419461 ENST00000469607	H7C5B6 [Direct mapping] Thyroid peroxidase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004447 [iodide peroxidase activity] GO:0004601 [peroxidase activity] GO:0006590 [thyroid hormone generation] GO:0006979 [response to oxidative stress] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	363 aa 40.7 kDa	No	1
TPO-201 ENSP00000318820 ENST00000345913	P07202 [Direct mapping] Thyroid peroxidase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0004447 [iodide peroxidase activity] GO:0004601 [peroxidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006590 [thyroid hormone generation] GO:0006979 [response to oxidative stress] GO:0009986 [cell surface] GO:0020037 [heme binding] GO:0033993 [response to lipid] GO:0034641 [cellular nitrogen compound metabolic process] GO:0035162 [embryonic hemopoiesis] GO:0042446 [hormone biosynthetic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0071732 [cellular response to nitric oxide] Show all	933 aa 103 kDa	Yes	1
TPO-202 ENSP00000263886 ENST00000346956	P07202 [Direct mapping] Thyroid peroxidase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0004447 [iodide peroxidase activity] GO:0004601 [peroxidase activity] GO:0005509 [calcium ion binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006590 [thyroid hormone generation] GO:0006979 [response to oxidative stress] GO:0009986 [cell surface] GO:0020037 [heme binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0035162 [embryonic hemopoiesis] GO:0042446 [hormone biosynthetic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	889 aa 98.3 kDa	Yes	1
TPO-203 ENSP00000444840 ENST00000539820	E9PFM6 [Direct mapping] Thyroid peroxidase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0004447 [iodide peroxidase activity] GO:0006590 [thyroid hormone generation] GO:0016021 [integral component of membrane] GO:0055114 [oxidation-reduction process] Show all	174 aa 19.3 kDa	Yes	0

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The Human Protein Atlas project is funded
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