Expression of HPCAL1 in cancer - Summary - The Human Protein Atlas

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HPCAL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HPCAL1
Gene description	Hippocalcin-like 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA043245
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and glioma (unfavourable).
Renal cancer p<0.001 Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043245

GENE INFORMATION
Gene name	HPCAL1 (HGNC Symbol)
Synonyms	BDR1, HLP2, VILIP-3
Description	Hippocalcin-like 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2012]
Chromosome	2
Cytoband	p25.1
Chromosome location (bp)	10302889 - 10427617
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115756 (version 83.38)
Entrez gene	3241
UniProt	P37235 (UniProt - Evidence at protein level)
neXtProt	NX_P37235
Antibodypedia	HPCAL1 antibodies

PROTEIN BROWSER

HPCAL1-001	HPCAL1-002	HPCAL1-004	HPCAL1-005	HPCAL1-201	HPCAL1-202	HPCAL1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HPCAL1-001 ENSP00000310749 ENST00000307845	P37235 [Direct mapping] Hippocalcin-like protein 1 Q6FGY1 [Target identity:100%; Query identity:100%] HPCAL1 protein; Hippocalcin-like 1; Hippocalcin-like 1, isoform CRA_a; Putative uncharacterized protein HPCAL1; cDNA FLJ78291, highly similar to Homo sapiens hippocalcin-like 1 (HPCAL1), transcript variant 2, mRNA Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0070062 [extracellular exosome] Show all	193 aa 22.3 kDa	No	0
HPCAL1-002 ENSP00000371184 ENST00000381765	P37235 [Direct mapping] Hippocalcin-like protein 1 Q6FGY1 [Target identity:100%; Query identity:100%] HPCAL1 protein; Hippocalcin-like 1; Hippocalcin-like 1, isoform CRA_a; Putative uncharacterized protein HPCAL1; cDNA FLJ78291, highly similar to Homo sapiens hippocalcin-like 1 (HPCAL1), transcript variant 2, mRNA Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0070062 [extracellular exosome] Show all	193 aa 22.3 kDa	No	0
HPCAL1-004 ENSP00000413689 ENST00000423674	C9JW46 [Direct mapping] Hippocalcin-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0007165 [signal transduction] Show all	30 aa 3.7 kDa	No	0
HPCAL1-005 ENSP00000388856 ENST00000422133	H7BZC1 [Direct mapping] Hippocalcin-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0007165 [signal transduction] Show all	103 aa 11.5 kDa	No	0
HPCAL1-201 ENSP00000478231 ENST00000613496	P37235 [Direct mapping] Hippocalcin-like protein 1 Q6FGY1 [Target identity:100%; Query identity:100%] HPCAL1 protein; Hippocalcin-like 1; Hippocalcin-like 1, isoform CRA_a; Putative uncharacterized protein HPCAL1; cDNA FLJ78291, highly similar to Homo sapiens hippocalcin-like 1 (HPCAL1), transcript variant 2, mRNA Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0070062 [extracellular exosome] Show all	193 aa 22.3 kDa	No	0
HPCAL1-202 ENSP00000483786 ENST00000620771	P37235 [Direct mapping] Hippocalcin-like protein 1 Q6FGY1 [Target identity:100%; Query identity:100%] HPCAL1 protein; Hippocalcin-like 1; Hippocalcin-like 1, isoform CRA_a; Putative uncharacterized protein HPCAL1; cDNA FLJ78291, highly similar to Homo sapiens hippocalcin-like 1 (HPCAL1), transcript variant 2, mRNA Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0070062 [extracellular exosome] Show all	193 aa 22.3 kDa	No	0
HPCAL1-203 ENSP00000482993 ENST00000622018	P37235 [Direct mapping] Hippocalcin-like protein 1 Q6FGY1 [Target identity:100%; Query identity:100%] HPCAL1 protein; Hippocalcin-like 1; Hippocalcin-like 1, isoform CRA_a; Putative uncharacterized protein HPCAL1; cDNA FLJ78291, highly similar to Homo sapiens hippocalcin-like 1 (HPCAL1), transcript variant 2, mRNA Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0070062 [extracellular exosome] Show all	193 aa 22.3 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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