Tissue expression of BIRC6 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	BIRC6
Gene description	Baculoviral IAP repeat containing 6
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	BIRC6 (HGNC Symbol)
Synonyms	BRUCE
Description	Baculoviral IAP repeat containing 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p22.3
Chromosome location (bp)	32357028 - 32618899
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115760 (version 83.38)
Entrez gene	57448
UniProt	Q9NR09 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NR09
Antibodypedia	BIRC6 antibodies

PROTEIN BROWSER

BIRC6-001	BIRC6-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BIRC6-001 ENSP00000393596 ENST00000421745	Q9NR09 [Direct mapping] Baculoviral IAP repeat-containing protein 6 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0001890 [placenta development] GO:0004842 [ubiquitin-protein transferase activity] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005802 [trans-Golgi network] GO:0005815 [microtubule organizing center] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007067 [mitotic nuclear division] GO:0008284 [positive regulation of cell proliferation] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030496 [midbody] GO:0032465 [regulation of cytokinesis] GO:0042127 [regulation of cell proliferation] GO:0043066 [negative regulation of apoptotic process] GO:0051301 [cell division] GO:0060711 [labyrinthine layer development] GO:0060712 [spongiotrophoblast layer development] GO:0061631 [ubiquitin conjugating enzyme activity] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] Show all	4857 aa 530.3 kDa	No	0
BIRC6-003 ENSP00000413090 ENST00000444173	H7C3P0 [Direct mapping] Baculoviral IAP repeat-containing protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	191 aa 20.8 kDa	No	0