Expression of NOL10 in cancer - Summary - The Human Protein Atlas

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NOL10

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NOL10
Gene description	Nucleolar protein 10
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA043075
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), endometrial cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Endometrial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043075

GENE INFORMATION
Gene name	NOL10 (HGNC Symbol)
Synonyms	FLJ14075, PQBP5
Description	Nucleolar protein 10 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	p25.1
Chromosome location (bp)	10570766 - 10689987
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115761 (version 83.38)
Entrez gene	79954
UniProt	Q9BSC4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BSC4
Antibodypedia	NOL10 antibodies

PROTEIN BROWSER

NOL10-001	NOL10-002	NOL10-004	NOL10-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NOL10-001 ENSP00000371101 ENST00000381685	Q9BSC4 [Direct mapping] Nucleolar protein 10 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0044822 [poly(A) RNA binding] Show all	688 aa 80.3 kDa	No	0
NOL10-002 ENSP00000263837 ENST00000345985	Q9BSC4 [Direct mapping] Nucleolar protein 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0044822 [poly(A) RNA binding] Show all	638 aa 74.5 kDa	No	0
NOL10-004 ENSP00000403170 ENST00000431319	H7C1Z3 [Direct mapping] Nucleolar protein 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	252 aa 28.3 kDa	No	0
NOL10-201 ENSP00000439663 ENST00000538384	Q9BSC4 [Direct mapping] Nucleolar protein 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0044822 [poly(A) RNA binding] Show all	662 aa 77.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.