Cell atlas - PRKD3 - The Human Protein Atlas

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PRKD3

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PRKD3
Gene description	Protein kinase D3
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA029529
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA029529	A-431	Nucleoplasm
	HPA029529	A-431	Cytosol
	HPA029529	U-2 OS	Nucleoplasm
	HPA029529	U-2 OS	Cytosol
	HPA029529	U-251 MG	Nucleoplasm
	HPA029529	U-251 MG	Cytosol

GENE INFORMATION
Gene name	PRKD3 (HGNC Symbol)
Synonyms	EPK2, PRKCN
Description	Protein kinase D3 (HGNC Symbol)
Entrez gene summary	This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]
Chromosome	2
Cytoband	p22.2
Chromosome location (bp)	37250502 - 37324808
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115825 (version 83.38)
Entrez gene	23683
UniProt	O94806 (UniProt - Evidence at protein level)
neXtProt	NX_O94806
Antibodypedia	PRKD3 antibodies

PROTEIN BROWSER

PRKD3-001	PRKD3-004	PRKD3-007	PRKD3-008	PRKD3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRKD3-001 ENSP00000368356 ENST00000379066	O94806 [Direct mapping] Serine/threonine-protein kinase D3 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004697 [protein kinase C activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding] Show all	890 aa 100.5 kDa	No	0
PRKD3-004 ENSP00000401839 ENST00000443187	C9JKP8 [Direct mapping] Serine/threonine-protein kinase D3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004697 [protein kinase C activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding] Show all	181 aa 20.7 kDa	No	0
PRKD3-007 ENSP00000398743 ENST00000443977	H7C172 [Direct mapping] Serine/threonine-protein kinase D3 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004697 [protein kinase C activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	173 aa 18.9 kDa	No	0
PRKD3-008 ENSP00000399540 ENST00000452104	H0Y5M6 [Direct mapping] Serine/threonine-protein kinase D3 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004697 [protein kinase C activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	185 aa 20.6 kDa	No	0
PRKD3-201 ENSP00000234179 ENST00000234179	O94806 [Direct mapping] Serine/threonine-protein kinase D3 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004697 [protein kinase C activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding] Show all	890 aa 100.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.