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Cell line enhanced (SCLC-21H, SK-MEL-30, U-266/84)
HPA (normal tissue):
Tissue enhanced (adrenal gland, epididymis)
Protein evidence
Evidence at protein level
Protein expression normal tissue
Cytoplasmic expression in most tissues
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Most cancer tissues were weakly stained or negative. A majority of carcinoids showed moderate to strong cytoplasmic staining.
GENE INFORMATION
Gene name
QPCT (HGNC Symbol)
Synonyms
GCT, QC
Description
Glutaminyl-peptide cyclotransferase (HGNC Symbol)
Entrez gene summary
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]