Tissue expression of DLX2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DLX2
Gene description	Distal-less homeobox 2
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Not detected
GTEx:	Tissue enhanced (hypothalamus)
FANTOM5:	Group enriched (brain, caudate, hippocampus, testis, thyroid gland)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Not detected
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (hypothalamus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (brain, caudate, hippocampus, testis, thyroid gland)

GENE INFORMATION
Gene name	DLX2 (HGNC Symbol)
Synonyms	TES-1
Description	Distal-less homeobox 2 (HGNC Symbol)
Entrez gene summary	Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	172099439 - 172102900
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115844 (version 83.38)
Entrez gene	1746
UniProt	Q07687 (UniProt - Evidence at protein level)
neXtProt	NX_Q07687
Antibodypedia	DLX2 antibodies

PROTEIN BROWSER

DLX2-001	DLX2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DLX2-001 ENSP00000234198 ENST00000234198	Q07687 [Direct mapping] Homeobox protein DLX-2 Q53QU7 [Target identity:100%; Query identity:100%] Distal-less homeobox 2; Putative uncharacterized protein DLX2; cDNA FLJ75693, highly similar to Homo sapiens distal-less homeo box 2 (DLX2), mRNA X5D7D8 [Target identity:100%; Query identity:100%] Distal-less homeobox 2 isoform A Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003727 [single-stranded RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007420 [brain development] GO:0009954 [proximal/distal pattern formation] GO:0021544 [subpallium development] GO:0021766 [hippocampus development] GO:0021772 [olfactory bulb development] GO:0021879 [forebrain neuron differentiation] GO:0021882 [regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment] GO:0021892 [cerebral cortex GABAergic interneuron differentiation] GO:0021893 [cerebral cortex GABAergic interneuron fate commitment] GO:0030154 [cell differentiation] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0043565 [sequence-specific DNA binding] GO:0045746 [negative regulation of Notch signaling pathway] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0048706 [embryonic skeletal system development] GO:0048715 [negative regulation of oligodendrocyte differentiation] GO:0048755 [branching morphogenesis of a nerve] GO:0051216 [cartilage development] Show all	328 aa 34.2 kDa	No	0
DLX2-002 ENSP00000446904 ENST00000466293	Q07687 [Direct mapping] Homeobox protein DLX-2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007420 [brain development] Show all	217 aa 23 kDa	No	0