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SRSF7

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GENERAL INFORMATION

Gene name

 SRSF7

Gene description

 Serine/arginine-rich splicing factor 7

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

siRNA

 The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA043850 , HPA056926
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ASSAYS
RNA expression
Human cells
siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA043850 A-431 Nucleoplasm
HPA043850 U-2 OS Nucleoplasm
HPA043850 U-251 MG Nucleoplasm
HPA056926 A-431 Nucleoplasm
HPA056926 U-2 OS Nucleoplasm
HPA056926 U-251 MG No staining    

siRNA VALIDATION

Antibody

 HPA043850

siRNA validation

 Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

 Nuclear region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

 64%69%

p-value

 < 0.01< 0.01
 

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail 10x

Thumbnail 40x

Antibody

Sample

Cell line
HPA043850 siRNA 1 U-2 OS
HPA043850 siRNA 2 U-2 OS
HPA043850 scrambled U-2 OS

GENE INFORMATION

Gene name

 SRSF7 (HGNC Symbol)

Synonyms

 9G8, AAG3, HSSG1, RBM37, SFRS7, ZCCHC20, ZCRB2

Description

 Serine/arginine-rich splicing factor 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Chromosome

 2

Cytoband

 p22.1

Chromosome location (bp)

 38743599 - 38751494

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115875 (version 83.38)

Entrez gene

 6432

UniProt

 Q16629 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16629

Antibodypedia

 SRSF7 antibodies

PROTEIN BROWSER
SRSF7-001
SRSF7-007
SRSF7-012
SRSF7-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRSF7-001
ENSP00000325905
ENST00000313117
Q16629 [Direct mapping]
Serine/arginine-rich splicing factor 7
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0031124 [mRNA 3'-end processing]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0070062 [extracellular exosome]
Show all
 238 aa
27.4 kDa 		No 0
SRSF7-007
ENSP00000392300
ENST00000452806
H7BZZ6 [Direct mapping]
Serine/arginine-rich-splicing factor 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 110 aa
12.8 kDa 		No 0
SRSF7-012
ENSP00000386806
ENST00000409276
C9JAB2 [Direct mapping]
Serine/arginine-rich-splicing factor 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0008270 [zinc ion binding]
Show all
 235 aa
26.9 kDa 		No 0
SRSF7-201
ENSP00000402264
ENST00000446327
Q16629 [Direct mapping]
Serine/arginine-rich splicing factor 7
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0008270 [zinc ion binding]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0031124 [mRNA 3'-end processing]
GO:0044822 [poly(A) RNA binding]
GO:0048025 [negative regulation of mRNA splicing, via spliceosome]
GO:0070062 [extracellular exosome]
Show all
 226 aa
26 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.