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SLC1A4

GENERAL INFORMATION

Gene name

 SLC1A4

Gene description

 Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4

Protein class

 Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, often with a membranous pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA034964
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), cervical cancer (favourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Cervical cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA034964

GENE INFORMATION

Gene name

 SLC1A4 (HGNC Symbol)

Synonyms

 ASCT1, SATT

Description

 Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 p14

Chromosome location (bp)

 64988477 - 65023865

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115902 (version 83.38)

Entrez gene

 6509

UniProt

 P43007 (UniProt - Evidence at protein level)

neXtProt

 NX_P43007

Antibodypedia

 SLC1A4 antibodies

PROTEIN BROWSER
SLC1A4-001
SLC1A4-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC1A4-001
ENSP00000234256
ENST00000234256
P43007 [Direct mapping]
Neutral amino acid transporter A
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005254 [chloride channel activity]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0006835 [dicarboxylic acid transport]
GO:0006865 [amino acid transport]
GO:0006868 [glutamine transport]
GO:0009986 [cell surface]
GO:0015175 [neutral amino acid transmembrane transporter activity]
GO:0015180 [L-alanine transmembrane transporter activity]
GO:0015184 [L-cystine transmembrane transporter activity]
GO:0015186 [L-glutamine transmembrane transporter activity]
GO:0015193 [L-proline transmembrane transporter activity]
GO:0015194 [L-serine transmembrane transporter activity]
GO:0015195 [L-threonine transmembrane transporter activity]
GO:0015808 [L-alanine transport]
GO:0015811 [L-cystine transport]
GO:0015824 [proline transport]
GO:0015825 [L-serine transport]
GO:0015826 [threonine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017153 [sodium:dicarboxylate symporter activity]
GO:0030425 [dendrite]
GO:0034589 [hydroxyproline transport]
GO:0034590 [L-hydroxyproline transmembrane transporter activity]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0035524 [proline transmembrane transport]
GO:0042470 [melanosome]
GO:0043025 [neuronal cell body]
GO:0050890 [cognition]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1902476 [chloride transmembrane transport]
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 532 aa
55.7 kDa 		No 9
SLC1A4-005
ENSP00000431942
ENST00000531327
P43007 [Direct mapping]
Neutral amino acid transporter A
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005254 [chloride channel activity]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0006835 [dicarboxylic acid transport]
GO:0006865 [amino acid transport]
GO:0006868 [glutamine transport]
GO:0009986 [cell surface]
GO:0015180 [L-alanine transmembrane transporter activity]
GO:0015184 [L-cystine transmembrane transporter activity]
GO:0015186 [L-glutamine transmembrane transporter activity]
GO:0015193 [L-proline transmembrane transporter activity]
GO:0015194 [L-serine transmembrane transporter activity]
GO:0015195 [L-threonine transmembrane transporter activity]
GO:0015808 [L-alanine transport]
GO:0015811 [L-cystine transport]
GO:0015824 [proline transport]
GO:0015825 [L-serine transport]
GO:0015826 [threonine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017153 [sodium:dicarboxylate symporter activity]
GO:0034589 [hydroxyproline transport]
GO:0034590 [L-hydroxyproline transmembrane transporter activity]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0035524 [proline transmembrane transport]
GO:0042470 [melanosome]
GO:0050890 [cognition]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1902476 [chloride transmembrane transport]
Show all
 234 aa
24.6 kDa 		Yes 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.