We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Son of sevenless homolog 1 (Drosophila) (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]
Q07889 [Direct mapping] Son of sevenless homolog 1
Show all
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001782 [B cell homeostasis] GO:0002260 [lymphocyte homeostasis] GO:0003677 [DNA binding] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005088 [Ras guanyl-nucleotide exchange factor activity] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0014069 [postsynaptic density] GO:0017124 [SH3 domain binding] GO:0030168 [platelet activation] GO:0033081 [regulation of T cell differentiation in thymus] GO:0035023 [regulation of Rho protein signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042129 [regulation of T cell proliferation] GO:0043025 [neuronal cell body] GO:0043065 [positive regulation of apoptotic process] GO:0043547 [positive regulation of GTPase activity] GO:0045087 [innate immune response] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0051057 [positive regulation of small GTPase mediated signal transduction] GO:0097190 [apoptotic signaling pathway] GO:2000973 [regulation of pro-B cell differentiation]
G5E9C8 [Direct mapping] Son of sevenless homolog 1; Son of sevenless homolog 1 (Drosophila), isoform CRA_d
Show all
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0046982 [protein heterodimerization activity]
C9K0N6 [Direct mapping] Son of sevenless homolog 1
Show all
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
Q07889 [Direct mapping] Son of sevenless homolog 1
Show all
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)