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KYNU

GENERAL INFORMATION

Gene name

 KYNU

Gene description

 Kynureninase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (A549, HeLa, SiHa, U-87 MG)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, high expression in hepatocytes, renal tubules and lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA031686
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031686

GENE INFORMATION

Gene name

 KYNU

Synonyms

Description

 Kynureninase (HGNC Symbol)

Entrez gene summary

 Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

Chromosome

 2

Cytoband

 q22.2

Chromosome location (bp)

 142877498 - 143055832

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115919 (version 83.38)

Entrez gene

 8942

UniProt

 Q16719 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16719

Antibodypedia

 KYNU antibodies

PROTEIN BROWSER
KYNU-001
KYNU-002
KYNU-003
KYNU-004
KYNU-007
KYNU-008
KYNU-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KYNU-001
ENSP00000264170
ENST00000264170
Q16719 [Direct mapping]
Kynureninase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006569 [tryptophan catabolic process]
GO:0009435 [NAD biosynthetic process]
GO:0019441 [tryptophan catabolic process to kynurenine]
GO:0019442 [tryptophan catabolic process to acetyl-CoA]
GO:0019805 [quinolinate biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
GO:0030429 [kynureninase activity]
GO:0034341 [response to interferon-gamma]
GO:0034354 ['de novo' NAD biosynthetic process from tryptophan]
GO:0034516 [response to vitamin B6]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043420 [anthranilate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0097053 [L-kynurenine catabolic process]
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 465 aa
52.4 kDa 		No 0
KYNU-002
ENSP00000386731
ENST00000409512
Q16719 [Direct mapping]
Kynureninase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006569 [tryptophan catabolic process]
GO:0009435 [NAD biosynthetic process]
GO:0019805 [quinolinate biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
GO:0030429 [kynureninase activity]
GO:0034341 [response to interferon-gamma]
GO:0034354 ['de novo' NAD biosynthetic process from tryptophan]
GO:0034516 [response to vitamin B6]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043420 [anthranilate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0097053 [L-kynurenine catabolic process]
Show all
 465 aa
52.4 kDa 		No 0
KYNU-003
ENSP00000364928
ENST00000375773
Q16719 [Direct mapping]
Kynureninase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006569 [tryptophan catabolic process]
GO:0009435 [NAD biosynthetic process]
GO:0019805 [quinolinate biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
GO:0030429 [kynureninase activity]
GO:0034341 [response to interferon-gamma]
GO:0034354 ['de novo' NAD biosynthetic process from tryptophan]
GO:0034516 [response to vitamin B6]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043420 [anthranilate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0097053 [L-kynurenine catabolic process]
Show all
 307 aa
34.6 kDa 		No 0
KYNU-004
ENSP00000387296
ENST00000410015
B8ZZA3 [Direct mapping]
Kynureninase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006569 [tryptophan catabolic process]
GO:0009435 [NAD biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
GO:0030429 [kynureninase activity]
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 148 aa
16.7 kDa 		No 0
KYNU-007
ENSP00000484801
ENST00000621320
A0A087X297 [Direct mapping]
Kynureninase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006569 [tryptophan catabolic process]
GO:0009435 [NAD biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
GO:0030429 [kynureninase activity]
Show all
 236 aa
26.8 kDa 		No 0
KYNU-008
ENSP00000481930
ENST00000612147
A0A087WYM2 [Direct mapping]
Kynureninase
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   Phobius predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006569 [tryptophan catabolic process]
GO:0009435 [NAD biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
GO:0030429 [kynureninase activity]
Show all
 168 aa
18.9 kDa 		No 0
KYNU-009
ENSP00000482009
ENST00000613664
A0A087WYQ7 [Direct mapping]
Kynureninase
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006569 [tryptophan catabolic process]
GO:0009435 [NAD biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
GO:0030429 [kynureninase activity]
Show all
 157 aa
17.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.