Tissue expression of COX7A2L - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	COX7A2L
Gene description	Cytochrome c oxidase subunit VIIa polypeptide 2 like
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	COX7A2L (HGNC Symbol)
Synonyms	COX7AR, COX7RP, EB1, SIG81
Description	Cytochrome c oxidase subunit VIIa polypeptide 2 like (HGNC Symbol)
Entrez gene summary	Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p21
Chromosome location (bp)	42333546 - 42425088
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115944 (version 83.38)
Entrez gene	9167
UniProt	O14548 (UniProt - Evidence at protein level)
neXtProt	NX_O14548
Antibodypedia	COX7A2L antibodies

PROTEIN BROWSER

COX7A2L-001	COX7A2L-007	COX7A2L-008	COX7A2L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COX7A2L-001 ENSP00000367938 ENST00000378669	O14548 [Direct mapping] Cytochrome c oxidase subunit 7A-related protein, mitochondrial Q6FGA0 [Target identity:100%; Query identity:100%] COX7A2L protein; Cytochrome c oxidase subunit VIIa polypeptide 2 like, isoform CRA_a; Putative uncharacterized protein COX7A2L; cDNA FLJ35592 fis, clone SPLEN2007695, highly similar to Cytochrome c oxidase subunit VIIa-related protein, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005746 [mitochondrial respiratory chain] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:1902600 [hydrogen ion transmembrane transport] Show all	114 aa 12.6 kDa	No	1
COX7A2L-007 ENSP00000431039 ENST00000463055	E5RJZ1 [Direct mapping] Cytochrome c oxidase subunit 7A-related protein, mitochondrial Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005746 [mitochondrial respiratory chain] GO:1902600 [hydrogen ion transmembrane transport] Show all	79 aa 8.8 kDa	No	0
COX7A2L-008 ENSP00000429237 ENST00000468711	H0YBD2 [Direct mapping] Cytochrome c oxidase subunit 7A-related protein, mitochondrial Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005746 [mitochondrial respiratory chain] GO:1902600 [hydrogen ion transmembrane transport] Show all	95 aa 10.4 kDa	No	0
COX7A2L-201 ENSP00000234301 ENST00000234301	O14548 [Direct mapping] Cytochrome c oxidase subunit 7A-related protein, mitochondrial Q6FGA0 [Target identity:100%; Query identity:100%] COX7A2L protein; Cytochrome c oxidase subunit VIIa polypeptide 2 like, isoform CRA_a; Putative uncharacterized protein COX7A2L; cDNA FLJ35592 fis, clone SPLEN2007695, highly similar to Cytochrome c oxidase subunit VIIa-related protein, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005743 [mitochondrial inner membrane] GO:0005746 [mitochondrial respiratory chain] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:1902600 [hydrogen ion transmembrane transport] Show all	114 aa 12.6 kDa	No	1