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ATF2

GENERAL INFORMATION

Gene name

 ATF2

Gene description

 Activating transcription factor 2

Protein class

 Enzymes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA022134 , CAB003769
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA022134
CAB003769

GENE INFORMATION

Gene name

 ATF2 (HGNC Symbol)

Synonyms

 CRE-BP1, CREB2, HB16, TREB7

Description

 Activating transcription factor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 175072250 - 175168382

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115966 (version 83.38)

Entrez gene

 1386

UniProt

 P15336 (UniProt - Evidence at protein level)

neXtProt

 NX_P15336

Antibodypedia

 ATF2 antibodies

PROTEIN BROWSER
«
ATF2-001
ATF2-002
ATF2-009
ATF2-011
ATF2-012
ATF2-013
ATF2-014
ATF2-015
ATF2-021
ATF2-201
ATF2-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATF2-001
ENSP00000264110
ENST00000264110
P15336 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003151 [outflow tract morphogenesis]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006970 [response to osmotic stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008134 [transcription factor binding]
GO:0008140 [cAMP response element binding protein binding]
GO:0009414 [response to water deprivation]
GO:0016020 [membrane]
GO:0016573 [histone acetylation]
GO:0019901 [protein kinase binding]
GO:0031573 [intra-S DNA damage checkpoint]
GO:0032915 [positive regulation of transforming growth factor beta2 production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035497 [cAMP response element binding]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035861 [site of double-strand break]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045444 [fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0060612 [adipose tissue development]
GO:0097186 [amelogenesis]
GO:1902110 [positive regulation of mitochondrial membrane permeability involved in apoptotic process]
Show all
 505 aa
54.5 kDa 		No 0
ATF2-002
ENSP00000376327
ENST00000392544
P15336 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006970 [response to osmotic stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008140 [cAMP response element binding protein binding]
GO:0016573 [histone acetylation]
GO:0019901 [protein kinase binding]
GO:0031573 [intra-S DNA damage checkpoint]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035497 [cAMP response element binding]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035861 [site of double-strand break]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:1902110 [positive regulation of mitochondrial membrane permeability involved in apoptotic process]
Show all
 505 aa
54.5 kDa 		No 0
ATF2-009
ENSP00000386526
ENST00000409833
P15336 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006970 [response to osmotic stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008140 [cAMP response element binding protein binding]
GO:0016573 [histone acetylation]
GO:0019901 [protein kinase binding]
GO:0031573 [intra-S DNA damage checkpoint]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035497 [cAMP response element binding]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035861 [site of double-strand break]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:1902110 [positive regulation of mitochondrial membrane permeability involved in apoptotic process]
Show all
 209 aa
23 kDa 		No 0
ATF2-011
ENSP00000386326
ENST00000409437
B8ZZU6 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
Show all
 389 aa
42.3 kDa 		No 0
ATF2-012
ENSP00000387093
ENST00000409635
P15336 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006970 [response to osmotic stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008140 [cAMP response element binding protein binding]
GO:0016573 [histone acetylation]
GO:0019901 [protein kinase binding]
GO:0031573 [intra-S DNA damage checkpoint]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035497 [cAMP response element binding]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035861 [site of double-strand break]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:1902110 [positive regulation of mitochondrial membrane permeability involved in apoptotic process]
Show all
 447 aa
48 kDa 		No 0
ATF2-013
ENSP00000340576
ENST00000345739
P15336 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006970 [response to osmotic stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008140 [cAMP response element binding protein binding]
GO:0016573 [histone acetylation]
GO:0019901 [protein kinase binding]
GO:0031573 [intra-S DNA damage checkpoint]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035497 [cAMP response element binding]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035861 [site of double-strand break]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:1902110 [positive regulation of mitochondrial membrane permeability involved in apoptotic process]
Show all
 447 aa
48 kDa 		No 0
ATF2-014
ENSP00000386282
ENST00000409499
P15336 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006970 [response to osmotic stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008140 [cAMP response element binding protein binding]
GO:0016573 [histone acetylation]
GO:0019901 [protein kinase binding]
GO:0031573 [intra-S DNA damage checkpoint]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035497 [cAMP response element binding]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035861 [site of double-strand break]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:1902110 [positive regulation of mitochondrial membrane permeability involved in apoptotic process]
Show all
 144 aa
15.4 kDa 		No 0
ATF2-015
ENSP00000416854
ENST00000437522
C9JCI8 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 189 aa
20.3 kDa 		No 0
ATF2-021
ENSP00000406995
ENST00000435004
H7C2N6 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
Show all
 265 aa
30 kDa 		No 0
ATF2-201
ENSP00000407911
ENST00000426833
P15336 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003713 [transcription coactivator activity]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006970 [response to osmotic stress]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008140 [cAMP response element binding protein binding]
GO:0016573 [histone acetylation]
GO:0019901 [protein kinase binding]
GO:0031573 [intra-S DNA damage checkpoint]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035497 [cAMP response element binding]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035861 [site of double-strand break]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:1902110 [positive regulation of mitochondrial membrane permeability involved in apoptotic process]
Show all
 487 aa
52.3 kDa 		No 0
ATF2-202
ENSP00000437952
ENST00000538946
F5H629 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
Show all
 329 aa
35 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.