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TRAK2

GENERAL INFORMATION

Gene name

 TRAK2

Gene description

 Trafficking protein, kinesin binding 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA015827
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA015827

GENE INFORMATION

Gene name

 TRAK2 (HGNC Symbol)

Synonyms

 ALS2CR3, CALS-C, GRIF-1, KIAA0549, MILT2, OIP98

Description

 Trafficking protein, kinesin binding 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q33.1

Chromosome location (bp)

 201377207 - 201451611

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115993 (version 83.38)

Entrez gene

 66008

UniProt

 O60296 (UniProt - Evidence at protein level)

neXtProt

 NX_O60296

Antibodypedia

 TRAK2 antibodies

PROTEIN BROWSER
TRAK2-001
TRAK2-002
TRAK2-004
TRAK2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRAK2-001
ENSP00000328875
ENST00000332624
O60296 [Direct mapping]
Trafficking kinesin-binding protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006493 [protein O-linked glycosylation]
GO:0006605 [protein targeting]
GO:0019899 [enzyme binding]
GO:0050811 [GABA receptor binding]
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 914 aa
101.4 kDa 		No 0
TRAK2-002
ENSP00000409333
ENST00000430254
O60296 [Direct mapping]
Trafficking kinesin-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0050811 [GABA receptor binding]
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 311 aa
35.8 kDa 		No 0
TRAK2-004
ENSP00000388254
ENST00000440597
Q53RS6 [Direct mapping]
Putative uncharacterized protein ALS2CR3; Trafficking kinesin-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 30 aa
3.3 kDa 		No 0
TRAK2-201
ENSP00000482435
ENST00000620184
A0A087WZ79 [Direct mapping]
Trafficking kinesin-binding protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 779 aa
86.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.