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TIA1

GENERAL INFORMATION

Gene name

 TIA1

Gene description

 TIA1 cytotoxic granule-associated RNA binding protein

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (favourable) and lung cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 TIA1

Synonyms

Description

 TIA1 cytotoxic granule-associated RNA binding protein (HGNC Symbol)

Entrez gene summary

 The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p13.3

Chromosome location (bp)

 70209444 - 70248660

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116001 (version 83.38)

Entrez gene

 7072

UniProt

 P31483 (UniProt - Evidence at protein level)

neXtProt

 NX_P31483

Antibodypedia

 TIA1 antibodies

PROTEIN BROWSER
TIA1-001
TIA1-002
TIA1-003
TIA1-004
TIA1-006
TIA1-013
TIA1-023

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TIA1-001
ENSP00000401371
ENST00000433529
P31483 [Direct mapping]
Nucleolysin TIA-1 isoform p40
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0008143 [poly(A) binding]
GO:0010494 [cytoplasmic stress granule]
GO:0017091 [AU-rich element binding]
GO:0017148 [negative regulation of translation]
GO:0030529 [ribonucleoprotein complex]
GO:0042036 [negative regulation of cytokine biosynthetic process]
GO:0044822 [poly(A) RNA binding]
GO:0048024 [regulation of mRNA splicing, via spliceosome]
GO:0097165 [nuclear stress granule]
GO:1904037 [positive regulation of epithelial cell apoptotic process]
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 386 aa
43 kDa 		No 0
TIA1-002
ENSP00000404023
ENST00000415783
P31483 [Direct mapping]
Nucleolysin TIA-1 isoform p40
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0008143 [poly(A) binding]
GO:0010494 [cytoplasmic stress granule]
GO:0044822 [poly(A) RNA binding]
GO:0048024 [regulation of mRNA splicing, via spliceosome]
GO:0097165 [nuclear stress granule]
Show all
 375 aa
41.8 kDa 		No 0
TIA1-003
ENSP00000399567
ENST00000445587
C9JTN7 [Direct mapping]
Nucleolysin TIA-1 isoform p40
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 285 aa
31.6 kDa 		No 0
TIA1-004
ENSP00000413751
ENST00000416149
P31483 [Direct mapping]
Nucleolysin TIA-1 isoform p40
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0008143 [poly(A) binding]
GO:0010494 [cytoplasmic stress granule]
GO:0044822 [poly(A) RNA binding]
GO:0048024 [regulation of mRNA splicing, via spliceosome]
GO:0097165 [nuclear stress granule]
Show all
 214 aa
24.1 kDa 		No 0
TIA1-006
ENSP00000282574
ENST00000282574
F8W8I6 [Direct mapping]
Nucleolysin TIA-1 isoform p40
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
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 385 aa
42.8 kDa 		No 0
TIA1-013
ENSP00000402263
ENST00000454815
F8WE16 [Direct mapping]
Nucleolysin TIA-1 isoform p40
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
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 114 aa
13.1 kDa 		No 0
TIA1-023
ENSP00000354838
ENST00000361692
H7BY49 [Direct mapping]
Nucleolysin TIA-1 isoform p40
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
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 152 aa
16.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.