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Most cancers showed weak to moderate cytoplasmic staining with granular pattern and additional luminal membranous positivity in a few cases. Gliomas, lymphomas and a majority of squamous cell carcinomas, prostate, ovarian and urothelial cancers were negative.
GENE INFORMATION
Gene name
PCYOX1 (HGNC Symbol)
Synonyms
KIAA0908, PCL1
Description
Prenylcysteine oxidase 1 (HGNC Symbol)
Entrez gene summary
Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]