Cell atlas - KISS1R - The Human Protein Atlas

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KISS1R

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane
	Vesicles

Human cell
	Plasma Membrane
	Vesicles

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GENERAL INFORMATION
Gene name	KISS1R
Gene description	KISS1 receptor
Protein class	Disease related genes G-protein coupled receptors Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to vesicles.
RNA cell category	Cell line enhanced (RPMI-8226, SH-SY5Y, K-562, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)
Additional location	In addition localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA071913
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPMI-8226, SH-SY5Y, K-562, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to vesicles.

Main location

Plasma membrane (supported)

Additional location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071913	Hep G2	Vesicles
	HPA071913	Hep G2	Plasma membrane
	HPA071913	SH-SY5Y	No staining
	HPA071913	U-2 OS	No staining

GENE INFORMATION
Gene name	KISS1R (HGNC Symbol)
Synonyms	AXOR12, GPR54, HOT7T175
Description	KISS1 receptor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty. Mutations in this gene have been associated with hypogonadotropic hypogonadism and central precocious puberty. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	917287 - 921015
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116014 (version 83.38)
Entrez gene	84634
UniProt	Q969F8 (UniProt - Evidence at protein level)
neXtProt	NX_Q969F8
Antibodypedia	KISS1R antibodies

PROTEIN BROWSER

KISS1R-001	KISS1R-002	KISS1R-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KISS1R-001 ENSP00000234371 ENST00000234371	Q969F8 [Direct mapping] KiSS-1 receptor Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0000186 [activation of MAPKK activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0008188 [neuropeptide receptor activity] GO:0008285 [negative regulation of cell proliferation] GO:0008528 [G-protein coupled peptide receptor activity] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019722 [calcium-mediated signaling] GO:0042923 [neuropeptide binding] GO:0046887 [positive regulation of hormone secretion] GO:0050482 [arachidonic acid secretion] GO:0050806 [positive regulation of synaptic transmission] GO:0051496 [positive regulation of stress fiber assembly] Show all	398 aa 42.6 kDa	No	7
KISS1R-002 ENSP00000467666 ENST00000592648	K7EQ45 [Direct mapping] KiSS-1 receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	97 aa 10 kDa	No	1
KISS1R-003 ENSP00000475639 ENST00000606939	U3KQ86 [Direct mapping] KiSS-1 receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	226 aa 23.8 kDa	No	4

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.