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CD207

GENERAL INFORMATION

Gene name

 CD207

Gene description

 CD207 molecule, langerin

Protein class

 CD markers
Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (AN3-CA)
HPA (normal tissue):Tissue enriched (skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in Langerhans cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA011216 , CAB002222
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA011216
CAB002222

GENE INFORMATION

Gene name

 CD207 (HGNC Symbol)

Synonyms

 CLEC4K, Langerin

Description

 CD207 molecule, langerin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]

Chromosome

 2

Cytoband

 p13.3

Chromosome location (bp)

 70830214 - 70835822

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116031 (version 83.38)

Entrez gene

 50489

UniProt

 Q9UJ71 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJ71

Antibodypedia

 CD207 antibodies

PROTEIN BROWSER
CD207-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD207-001
ENSP00000386378
ENST00000410009
Q9UJ71 [Direct mapping]
C-type lectin domain family 4 member K
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
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GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0005537 [mannose binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0030139 [endocytic vesicle]
GO:0030246 [carbohydrate binding]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0031901 [early endosome membrane]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0051607 [defense response to virus]
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 328 aa
36.7 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.