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GRIN3B

GENERAL INFORMATION

Gene name

 GRIN3B

Gene description

 Glutamate receptor, ionotropic, N-methyl-D-aspartate 3B

Protein class

 FDA approved drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (U-266/70)
HPA (normal tissue):Tissue enhanced (fallopian tube, spleen)

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 GRIN3B (HGNC Symbol)

Synonyms

 GluN3B

Description

 Glutamate receptor, ionotropic, N-methyl-D-aspartate 3B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. [provided by RefSeq, Nov 2015]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 1000419 - 1009732

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000116032 (version 83.38)

Entrez gene

 116444

UniProt

 O60391 (UniProt - Evidence at transcript level)

neXtProt

 NX_O60391

Antibodypedia

 GRIN3B antibodies

PROTEIN BROWSER
GRIN3B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GRIN3B-001
ENSP00000234389
ENST00000234389
O60391 [Direct mapping]
Glutamate receptor ionotropic, NMDA 3B
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
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GO:0004970 [ionotropic glutamate receptor activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005234 [extracellular-glutamate-gated ion channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0016594 [glycine binding]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0030594 [neurotransmitter receptor activity]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0042165 [neurotransmitter binding]
GO:0043025 [neuronal cell body]
GO:0045211 [postsynaptic membrane]
GO:0051205 [protein insertion into membrane]
GO:0051924 [regulation of calcium ion transport]
GO:0070588 [calcium ion transmembrane transport]
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 1043 aa
113 kDa 		Yes 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.