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NFE2L2

GENERAL INFORMATION

Gene name

 NFE2L2

Gene description

 Nuclear factor, erythroid 2-like 2

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA002990 , CAB020317
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA002990
CAB020317

GENE INFORMATION

Gene name

 NFE2L2 (HGNC Symbol)

Synonyms

 NRF2

Description

 Nuclear factor, erythroid 2-like 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]

Chromosome

 2

Cytoband

 q31.2

Chromosome location (bp)

 177227595 - 177392697

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116044 (version 83.38)

Entrez gene

 4780

UniProt

 Q16236 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16236

Antibodypedia

 NFE2L2 antibodies

PROTEIN BROWSER
«
NFE2L2-001
NFE2L2-002
NFE2L2-003
NFE2L2-006
NFE2L2-008
NFE2L2-009
NFE2L2-010
NFE2L2-012
NFE2L2-013
NFE2L2-014
NFE2L2-015
NFE2L2-016
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NFE2L2-001
ENSP00000380252
ENST00000397062
Q16236 [Direct mapping]
Nuclear factor erythroid 2-related factor 2
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0001221 [transcription cofactor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006954 [inflammatory response]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0010628 [positive regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019904 [protein domain specific binding]
GO:0030194 [positive regulation of blood coagulation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032993 [protein-DNA complex]
GO:0034599 [cellular response to oxidative stress]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035690 [cellular response to drug]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045454 [cell redox homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045995 [regulation of embryonic development]
GO:0046326 [positive regulation of glucose import]
GO:0060548 [negative regulation of cell death]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071498 [cellular response to fluid shear stress]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:1902037 [negative regulation of hematopoietic stem cell differentiation]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
GO:1903788 [positive regulation of glutathione biosynthetic process]
GO:2000121 [regulation of removal of superoxide radicals]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 605 aa
67.8 kDa 		No 0
NFE2L2-002
ENSP00000380253
ENST00000397063
Q16236 [Direct mapping]
Nuclear factor erythroid 2-related factor 2
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0010628 [positive regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019904 [protein domain specific binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032993 [protein-DNA complex]
GO:0034599 [cellular response to oxidative stress]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071498 [cellular response to fluid shear stress]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
 589 aa
66.1 kDa 		No 0
NFE2L2-003
ENSP00000467401
ENST00000464747
Q16236 [Direct mapping]
Nuclear factor erythroid 2-related factor 2
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0010628 [positive regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019904 [protein domain specific binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032993 [protein-DNA complex]
GO:0034599 [cellular response to oxidative stress]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071498 [cellular response to fluid shear stress]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
 589 aa
66.1 kDa 		No 0
NFE2L2-006
ENSP00000410015
ENST00000423513
C9JFL6 [Direct mapping]
Nuclear factor erythroid 2-related factor 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0034599 [cellular response to oxidative stress]
Show all
 141 aa
16.9 kDa 		No 0
NFE2L2-008
ENSP00000411575
ENST00000446151
Q16236 [Direct mapping]
Nuclear factor erythroid 2-related factor 2
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0010628 [positive regulation of gene expression]
GO:0016567 [protein ubiquitination]
GO:0019904 [protein domain specific binding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032993 [protein-DNA complex]
GO:0034599 [cellular response to oxidative stress]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071498 [cellular response to fluid shear stress]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903206 [negative regulation of hydrogen peroxide-induced cell death]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
 582 aa
65.4 kDa 		No 0
NFE2L2-009
ENSP00000412191
ENST00000421929
C9J0Y1 [Direct mapping]
Nuclear factor erythroid 2-related factor 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0034599 [cellular response to oxidative stress]
Show all
 234 aa
26.7 kDa 		No 0
NFE2L2-010
ENSP00000391291
ENST00000430047
C9J3K4 [Direct mapping]
Nuclear factor erythroid 2-related factor 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0034599 [cellular response to oxidative stress]
Show all
 68 aa
7.6 kDa 		No 0
NFE2L2-012
ENSP00000391590
ENST00000449627
C9JBM0 [Direct mapping]
Nuclear factor erythroid 2-related factor 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0034599 [cellular response to oxidative stress]
GO:0043565 [sequence-specific DNA binding]
Show all
 265 aa
30.2 kDa 		No 0
NFE2L2-013
ENSP00000400073
ENST00000448782
C9J1A8 [Direct mapping]
Nuclear factor erythroid 2-related factor 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0034599 [cellular response to oxidative stress]
Show all
 280 aa
31.7 kDa 		No 0
NFE2L2-014
ENSP00000416308
ENST00000458603
H7C498 [Direct mapping]
Nuclear factor erythroid 2-related factor 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 47 aa
5.4 kDa 		No 0
NFE2L2-015
ENSP00000468089
ENST00000588123
K7ER33 [Direct mapping]
Nuclear factor erythroid 2-related factor 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0034599 [cellular response to oxidative stress]
Show all
 146 aa
16.9 kDa 		No 0
NFE2L2-016
ENSP00000464920
ENST00000586532
K7EIW5 [Direct mapping]
Nuclear factor erythroid 2-related factor 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0034599 [cellular response to oxidative stress]
Show all
 265 aa
30.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.