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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SPR
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    CELL

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SPR

Gene description

Sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA039505
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA039505

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells displayed moderate to strong cytoplasmic positivity with a granular pattern.

GENE INFORMATION

Gene name

SPR (HGNC Symbol)

Synonyms

SDR38C1

Description

Sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) (HGNC Symbol)

Entrez gene summary

This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p13.2

Chromosome location (bp)

72887360 - 72892158

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116096 (version 83.38)

Entrez gene

6697

UniProt

P35270 (UniProt - Evidence at protein level)

neXtProt

NX_P35270

Antibodypedia

SPR antibodies

PROTEIN BROWSER

SPR-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPR-001
ENSP00000234454
ENST00000234454
P35270 [Direct mapping]
Sepiapterin reductase
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004033 [aldo-keto reductase (NADP) activity]
GO:0004757 [sepiapterin reductase activity]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006558 [L-phenylalanine metabolic process]
GO:0006729 [tetrahydrobiopterin biosynthetic process]
GO:0006809 [nitric oxide biosynthetic process]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0019889 [pteridine metabolic process]
GO:0040014 [regulation of multicellular organism growth]
GO:0042415 [norepinephrine metabolic process]
GO:0042417 [dopamine metabolic process]
GO:0042428 [serotonin metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046146 [tetrahydrobiopterin metabolic process]
GO:0046209 [nitric oxide metabolic process]
GO:0048667 [cell morphogenesis involved in neuron differentiation]
GO:0050661 [NADP binding]
GO:0050882 [voluntary musculoskeletal movement]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
261 aa
28 kDa
No 0

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