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EPHA4

GENERAL INFORMATION

Gene name

 EPHA4

Gene description

 EPH receptor A4

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (AF22, CACO-2, U-2197)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissue types, highly abundant in brain.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB028368
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and ovarian cancer (unfavourable).
Renal cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Thyroid cancer

STAINING SUMMARY
CAB028368

GENE INFORMATION

Gene name

 EPHA4 (HGNC Symbol)

Synonyms

 Hek8, TYRO1

Description

 EPH receptor A4 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

Chromosome

 2

Cytoband

 q36.1

Chromosome location (bp)

 221418027 - 221574202

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116106 (version 83.38)

Entrez gene

 2043

UniProt

 P54764 (UniProt - Evidence at protein level)

neXtProt

 NX_P54764

Antibodypedia

 EPHA4 antibodies

PROTEIN BROWSER
EPHA4-001
EPHA4-002
EPHA4-003
EPHA4-004
EPHA4-005
EPHA4-006
EPHA4-012
EPHA4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EPHA4-001
ENSP00000386829
ENST00000409938
P54764 [Direct mapping]
Ephrin type-A receptor 4
A0A024R452 [Target identity:100%; Query identity:100%]
Receptor protein-tyrosine kinase
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005004 [GPI-linked ephrin receptor activity]
GO:0005005 [transmembrane-ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0008045 [motor neuron axon guidance]
GO:0014069 [postsynaptic density]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021957 [corticospinal tract morphogenesis]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031901 [early endosome membrane]
GO:0042731 [PH domain binding]
GO:0043087 [regulation of GTPase activity]
GO:0045211 [postsynaptic membrane]
GO:0046777 [protein autophosphorylation]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048681 [negative regulation of axon regeneration]
GO:0048710 [regulation of astrocyte differentiation]
GO:0050770 [regulation of axonogenesis]
GO:0061001 [regulation of dendritic spine morphogenesis]
GO:0097155 [fasciculation of sensory neuron axon]
GO:0097156 [fasciculation of motor neuron axon]
GO:0097161 [DH domain binding]
GO:2001108 [positive regulation of Rho guanyl-nucleotide exchange factor activity]
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 986 aa
109.9 kDa 		Yes 2
EPHA4-002
ENSP00000444085
ENST00000541600
F5GZZ5 [Direct mapping]
Ephrin type-A receptor 4
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0048013 [ephrin receptor signaling pathway]
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 149 aa
17.2 kDa 		Yes 0
EPHA4-003
ENSP00000386276
ENST00000409854
E9PG71 [Direct mapping]
Receptor protein-tyrosine kinase
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0048013 [ephrin receptor signaling pathway]
Show all
 949 aa
105.7 kDa 		Yes 2
EPHA4-004
ENSP00000404089
ENST00000434266
C9JIX8 [Direct mapping]
Ephrin type-A receptor 4
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0048013 [ephrin receptor signaling pathway]
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 91 aa
10.3 kDa 		Yes 0
EPHA4-005
ENSP00000410158
ENST00000419964
C9JEM6 [Direct mapping]
Ephrin type-A receptor 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0048013 [ephrin receptor signaling pathway]
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 126 aa
14.9 kDa 		No 0
EPHA4-006
ENSP00000401405
ENST00000441679
H7C1N8 [Direct mapping]
Ephrin type-A receptor 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 189 aa
20.1 kDa 		No 0
EPHA4-012
ENSP00000395917
ENST00000443796
C9JFX5 [Direct mapping]
Ephrin type-A receptor 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 177 aa
19 kDa 		Yes 0
EPHA4-201
ENSP00000281821
ENST00000281821
P54764 [Direct mapping]
Ephrin type-A receptor 4
A0A024R452 [Target identity:100%; Query identity:100%]
Receptor protein-tyrosine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005004 [GPI-linked ephrin receptor activity]
GO:0005005 [transmembrane-ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0007628 [adult walking behavior]
GO:0008045 [motor neuron axon guidance]
GO:0008347 [glial cell migration]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0021957 [corticospinal tract morphogenesis]
GO:0030054 [cell junction]
GO:0030175 [filopodium]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031594 [neuromuscular junction]
GO:0031901 [early endosome membrane]
GO:0042731 [PH domain binding]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043087 [regulation of GTPase activity]
GO:0043197 [dendritic spine]
GO:0043204 [perikaryon]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043679 [axon terminus]
GO:0044295 [axonal growth cone]
GO:0044297 [cell body]
GO:0045211 [postsynaptic membrane]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048681 [negative regulation of axon regeneration]
GO:0048710 [regulation of astrocyte differentiation]
GO:0050770 [regulation of axonogenesis]
GO:0050775 [positive regulation of dendrite morphogenesis]
GO:0061001 [regulation of dendritic spine morphogenesis]
GO:0072178 [nephric duct morphogenesis]
GO:0097155 [fasciculation of sensory neuron axon]
GO:0097156 [fasciculation of motor neuron axon]
GO:0097161 [DH domain binding]
GO:2001108 [positive regulation of Rho guanyl-nucleotide exchange factor activity]
Show all
 986 aa
109.9 kDa 		Yes 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.