Expression of BCL9 in cancer - Summary - The Human Protein Atlas

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BCL9

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BCL9
Gene description	B-cell CLL/lymphoma 9
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA020274
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020274

GENE INFORMATION
Gene name	BCL9
Synonyms
Description	B-cell CLL/lymphoma 9 (HGNC Symbol)
Entrez gene summary	BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q21.2
Chromosome location (bp)	147541412 - 147626216
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116128 (version 83.38)
Entrez gene	607
UniProt	O00512 (UniProt - Evidence at protein level)
neXtProt	NX_O00512
Antibodypedia	BCL9 antibodies

PROTEIN BROWSER

BCL9-001	BCL9-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCL9-001 ENSP00000234739 ENST00000234739	O00512 [Direct mapping] B-cell CLL/lymphoma 9 protein A0A024QYY4 [Target identity:100%; Query identity:100%] B-cell CLL/lymphoma 9, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005801 [cis-Golgi network] GO:0008013 [beta-catenin binding] GO:0014908 [myotube differentiation involved in skeletal muscle regeneration] GO:0035019 [somatic stem cell population maintenance] GO:0035914 [skeletal muscle cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060070 [canonical Wnt signaling pathway] Show all	1426 aa 149.3 kDa	No	0
BCL9-201 ENSP00000479694 ENST00000622552	A0A087WVU5 [Direct mapping] B-cell CLL/lymphoma 9 protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		1394 aa 145.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.