Cell atlas - CACYBP - The Human Protein Atlas

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CACYBP

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CACYBP
Gene description	Calcyclin binding protein
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)
Additional location	In addition localized to the Nucleoplasm (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA025753 , HPA057038
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nucleoplasm.

Main location

Cytosol (validated)

Additional location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA025753	A-431	Nucleoplasm
HPA025753	A-431	Cytosol
HPA025753	U-2 OS	Cytosol
HPA025753	U-251 MG	Nucleoplasm
HPA025753	U-251 MG	Cytosol
HPA057038	A-431	Nucleoplasm
HPA057038	A-431	Cytosol
HPA057038	U-2 OS	Cytosol
HPA057038	U-251 MG	Cytosol

GENE INFORMATION
Gene name	CACYBP (HGNC Symbol)
Synonyms	S100A6BP, SIP
Description	Calcyclin binding protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q25.1
Chromosome location (bp)	174999163 - 175011715
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116161 (version 83.38)
Entrez gene	27101
UniProt	Q9HB71 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HB71
Antibodypedia	CACYBP antibodies

PROTEIN BROWSER

CACYBP-001	CACYBP-002	CACYBP-003	CACYBP-004	CACYBP-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CACYBP-001 ENSP00000356652 ENST00000367679	Q9HB71 [Direct mapping] Calcyclin-binding protein A0A024R904 [Target identity:100%; Query identity:100%] Calcyclin binding protein, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005641 [nuclear envelope lumen] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0030877 [beta-catenin destruction complex] GO:0042803 [protein homodimerization activity] GO:0070062 [extracellular exosome] Show all	228 aa 26.2 kDa	No	0
CACYBP-002 ENSP00000479414 ENST00000613570	Q9HB71 [Direct mapping] Calcyclin-binding protein Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0030877 [beta-catenin destruction complex] GO:0042803 [protein homodimerization activity] GO:0070062 [extracellular exosome] Show all	185 aa 21.2 kDa	No	0
CACYBP-003 ENSP00000403674 ENST00000426793	B2ZWH1 [Direct mapping] Calcyclin-binding protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		50 aa 5.9 kDa	No	0
CACYBP-004 ENSP00000385771 ENST00000405362	Q9HB71 [Direct mapping] Calcyclin-binding protein Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0030877 [beta-catenin destruction complex] GO:0042803 [protein homodimerization activity] GO:0070062 [extracellular exosome] Show all	185 aa 21.2 kDa	No	0
CACYBP-009 ENSP00000384139 ENST00000406752	Q9HB71 [Direct mapping] Calcyclin-binding protein Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0030877 [beta-catenin destruction complex] GO:0042803 [protein homodimerization activity] GO:0070062 [extracellular exosome] Show all	80 aa 9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.