Expression of NPHS2 in cancer - Summary - The Human Protein Atlas

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NPHS2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NPHS2
Gene description	Nephrosis 2, idiopathic, steroid-resistant (podocin)
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enriched (NTERA-2)
HPA (normal tissue):	Tissue enriched (kidney)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in renal glomeruli.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA049486 , CAB037267
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049486	CAB037267

GENE INFORMATION
Gene name	NPHS2 (HGNC Symbol)
Synonyms	PDCN, SRN1
Description	Nephrosis 2, idiopathic, steroid-resistant (podocin) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	1
Cytoband	q25.2
Chromosome location (bp)	179550539 - 179575952
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116218 (version 83.38)
Entrez gene	7827
UniProt	Q9NP85 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NP85
Antibodypedia	NPHS2 antibodies

PROTEIN BROWSER

NPHS2-001	NPHS2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPHS2-001 ENSP00000356587 ENST00000367615	Q9NP85 [Direct mapping] Podocin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0007588 [excretion] GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane] GO:0031532 [actin cytoskeleton reorganization] GO:0036057 [slit diaphragm] GO:0043234 [protein complex] GO:0045121 [membrane raft] GO:0070062 [extracellular exosome] GO:0072249 [metanephric glomerular visceral epithelial cell development] Show all	383 aa 42.2 kDa	No	1
NPHS2-002 ENSP00000356588 ENST00000367616	Q9NP85 [Direct mapping] Podocin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0007588 [excretion] GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane] GO:0031532 [actin cytoskeleton reorganization] GO:0036057 [slit diaphragm] GO:0043234 [protein complex] GO:0045121 [membrane raft] GO:0070062 [extracellular exosome] GO:0072249 [metanephric glomerular visceral epithelial cell development] Show all	315 aa 34.4 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.