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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ICMT
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ICMT

Gene description

Isoprenylcysteine carboxyl methyltransferase

Protein class

Enzymes
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Uncertain based on 2 antibodies.
HPA032024 , HPA032025
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PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA032024
HPA032025

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Colorectal, ovarian, endometrial, thyroid, squamous cell carcinomas and melanomas showed moderate cytoplasmic and membranous staining. Two cases of melanomas were strongly stained. Remaining cancers were however negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most tumour cells showed moderate cytoplasmic and membranous immunoreactivity. Cases of liver, gastric and colorectal cancers displayed strong immunoreactivity. Gliomas and lymphomas were weakly stained or negative.

GENE INFORMATION

Gene name

ICMT (HGNC Symbol)

Synonyms

HSTE14, PCCMT, PPMT

Description

Isoprenylcysteine carboxyl methyltransferase (HGNC Symbol)

Entrez gene summary

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.31

Chromosome location (bp)

6221193 - 6235972

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116237 (version 83.38)

Entrez gene

23463

UniProt

O60725 (UniProt - Evidence at protein level)

neXtProt

NX_O60725

Antibodypedia

ICMT antibodies

PROTEIN BROWSER

ICMT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ICMT-001
ENSP00000343552
ENST00000343813
O60725 [Direct mapping]
Protein-S-isoprenylcysteine O-methyltransferase
A0A024R4F6 [Target identity:100%; Query identity:100%]
Protein-S-isoprenylcysteine O-methyltransferase
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001701 [in utero embryonic development]
GO:0001889 [liver development]
GO:0003880 [protein C-terminal carboxyl O-methyltransferase activity]
GO:0004671 [protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006464 [cellular protein modification process]
GO:0006479 [protein methylation]
GO:0006481 [C-terminal protein methylation]
GO:0006612 [protein targeting to membrane]
GO:0008104 [protein localization]
GO:0008140 [cAMP response element binding protein binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035264 [multicellular organism growth]
GO:0046498 [S-adenosylhomocysteine metabolic process]
GO:0046499 [S-adenosylmethioninamine metabolic process]
GO:0046578 [regulation of Ras protein signal transduction]
Show all
284 aa
31.9 kDa
No 6

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