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CHD5

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GENERAL INFORMATION

Gene name

 CHD5

Gene description

 Chromodomain helicase DNA binding protein 5

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear speckles & nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Cell line enhanced (SCLC-21H, U-2 OS)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Nuclear speckles (supported)

Additional location

 In addition localized to the Cytosol (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA015809
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, U-2 OS)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear speckles & nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (supported), Nuclear speckles (supported)

Additional location

 Cytosol (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA015809 MCF7 Nucleoplasm
Nuclear speckles
HPA015809 PC-3 Nucleoplasm
Nuclear speckles
Cytosol
HPA015809 U-2 OS Nucleoplasm
Nuclear speckles
Cytosol

GENE INFORMATION

Gene name

 CHD5

Synonyms

Description

 Chromodomain helicase DNA binding protein 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. [provided by RefSeq, Feb 2012]

Chromosome

 1

Cytoband

 p36.31

Chromosome location (bp)

 6101793 - 6180123

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116254 (version 83.38)

Entrez gene

 26038

UniProt

 Q8TDI0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TDI0

Antibodypedia

 CHD5 antibodies

PROTEIN BROWSER
CHD5-001
CHD5-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHD5-001
ENSP00000262450
ENST00000262450
Q8TDI0 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 5
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000792 [heterochromatin]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008026 [ATP-dependent helicase activity]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0016020 [membrane]
GO:0016581 [NuRD complex]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0021895 [cerebral cortex neuron differentiation]
GO:0035093 [spermatogenesis, exchange of chromosomal proteins]
GO:0043967 [histone H4 acetylation]
GO:0060850 [regulation of transcription involved in cell fate commitment]
GO:0061628 [H3K27me3 modified histone binding]
GO:0098532 [histone H3-K27 trimethylation]
GO:1901798 [positive regulation of signal transduction by p53 class mediator]
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 1954 aa
223 kDa 		No 0
CHD5-003
ENSP00000466440
ENST00000475121
K7EMC0 [Direct mapping]
Chromodomain-helicase-DNA-binding protein 5
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Predicted intracellular proteins
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GO:0003677 [DNA binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
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 90 aa
10.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.