Cell atlas - KIAA1324 - The Human Protein Atlas

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KIAA1324

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	KIAA1324
Gene description	KIAA1324
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Cell line enhanced (T-47d, MCF7, SCLC-21H, SK-BR-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA070749
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d, MCF7, SCLC-21H, SK-BR-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA070749	MCF7	Plasma membrane
	HPA070749	U-2 OS	No staining

GENE INFORMATION
Gene name	KIAA1324 (HGNC Symbol)
Synonyms	EIG121, maba1
Description	KIAA1324 (HGNC Symbol)
Entrez gene summary	Expression of this gene is induced by estrogen and the encoded protein has been characterized as a transmembrane protein. The encoded protein has been found in to correlate with survival in certain carcinomas (PMID: 21102415) and may be important for cellular response to stress (PMID: 21072319). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Chromosome	1
Cytoband	p13.3
Chromosome location (bp)	109113679 - 109206781
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116299 (version 83.38)
Entrez gene	57535
UniProt	Q6UXG2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6UXG2
Antibodypedia	KIAA1324 antibodies

PROTEIN BROWSER

KIAA1324-002	KIAA1324-006	KIAA1324-008	KIAA1324-012	KIAA1324-013	KIAA1324-014	KIAA1324-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KIAA1324-002 ENSP00000358955 ENST00000369939	Q6UXG2 [Direct mapping] UPF0577 protein KIAA1324 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005770 [late endosome] GO:0005802 [trans-Golgi network] GO:0005887 [integral component of plasma membrane] GO:0009267 [cellular response to starvation] GO:0016236 [macroautophagy] GO:0031902 [late endosome membrane] GO:0044090 [positive regulation of vacuole organization] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] GO:2000786 [positive regulation of autophagosome assembly] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] Show all	1013 aa 111.4 kDa	Yes	1
KIAA1324-006 ENSP00000393964 ENST00000457623	E9PB18 [Direct mapping] UPF0577 protein KIAA1324 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	901 aa 99.4 kDa	Yes	1
KIAA1324-008 ENSP00000434595 ENST00000529753	Q6UXG2 [Direct mapping] UPF0577 protein KIAA1324 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005770 [late endosome] GO:0005802 [trans-Golgi network] GO:0005887 [integral component of plasma membrane] GO:0009267 [cellular response to starvation] GO:0016236 [macroautophagy] GO:0031902 [late endosome membrane] GO:0044090 [positive regulation of vacuole organization] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] GO:2000786 [positive regulation of autophagosome assembly] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] Show all	926 aa 102 kDa	Yes	1
KIAA1324-012 ENSP00000431134 ENST00000533147	E9PMS2 [Direct mapping] UPF0577 protein KIAA1324 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		91 aa 10.2 kDa	Yes	0
KIAA1324-013 ENSP00000431349 ENST00000531664	E9PLQ2 [Direct mapping] UPF0577 protein KIAA1324 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		205 aa 22.9 kDa	Yes	0
KIAA1324-014 ENSP00000432164 ENST00000534476	E9PS21 [Direct mapping] UPF0577 protein KIAA1324 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		152 aa 16.8 kDa	Yes	0
KIAA1324-015 ENSP00000435066 ENST00000526264	E9PLY8 [Direct mapping] UPF0577 protein KIAA1324 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		156 aa 17.2 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.