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GENE INFORMATION
Gene name
RAP1A (HGNC Symbol)
Synonyms
KREV-1, SMGP21
Description
RAP1A, member of RAS oncogene family (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
P62834 [Direct mapping] Ras-related protein Rap-1A A8KAH9 [Target identity:100%; Query identity:100%] RAP1A, member of RAS oncogene family; Ras-related protein Rap-1A; cDNA FLJ75985, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA
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Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000186 [activation of MAPKK activity] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0006886 [intracellular protein transport] GO:0006913 [nucleocytoplasmic transport] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007596 [blood coagulation] GO:0008565 [protein transporter activity] GO:0009743 [response to carbohydrate] GO:0010976 [positive regulation of neuron projection development] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0017016 [Ras GTPase binding] GO:0017034 [Rap guanyl-nucleotide exchange factor activity] GO:0030054 [cell junction] GO:0030168 [platelet activation] GO:0032045 [guanyl-nucleotide exchange factor complex] GO:0032403 [protein complex binding] GO:0032486 [Rap protein signal transduction] GO:0032966 [negative regulation of collagen biosynthetic process] GO:0035690 [cellular response to drug] GO:0038180 [nerve growth factor signaling pathway] GO:0043005 [neuron projection] GO:0043209 [myelin sheath] GO:0043547 [positive regulation of GTPase activity] GO:0044281 [small molecule metabolic process] GO:0045860 [positive regulation of protein kinase activity] GO:0046326 [positive regulation of glucose import] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050766 [positive regulation of phagocytosis] GO:0050796 [regulation of insulin secretion] GO:0061028 [establishment of endothelial barrier] GO:0070062 [extracellular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071320 [cellular response to cAMP] GO:0071333 [cellular response to glucose stimulus] GO:0071407 [cellular response to organic cyclic compound] GO:0097327 [response to antineoplastic agent] GO:0097421 [liver regeneration] GO:1901888 [regulation of cell junction assembly] GO:1990090 [cellular response to nerve growth factor stimulus] GO:2000301 [negative regulation of synaptic vesicle exocytosis] GO:2001214 [positive regulation of vasculogenesis]
P62834 [Direct mapping] Ras-related protein Rap-1A A8KAH9 [Target identity:100%; Query identity:100%] RAP1A, member of RAS oncogene family; Ras-related protein Rap-1A; cDNA FLJ75985, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA
Show all
Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0006886 [intracellular protein transport] GO:0006913 [nucleocytoplasmic transport] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007596 [blood coagulation] GO:0008565 [protein transporter activity] GO:0010976 [positive regulation of neuron projection development] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0017034 [Rap guanyl-nucleotide exchange factor activity] GO:0030054 [cell junction] GO:0030168 [platelet activation] GO:0032403 [protein complex binding] GO:0032486 [Rap protein signal transduction] GO:0038180 [nerve growth factor signaling pathway] GO:0043547 [positive regulation of GTPase activity] GO:0044281 [small molecule metabolic process] GO:0045860 [positive regulation of protein kinase activity] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050796 [regulation of insulin secretion] GO:0061028 [establishment of endothelial barrier] GO:0070062 [extracellular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071320 [cellular response to cAMP] GO:1901888 [regulation of cell junction assembly] GO:1990090 [cellular response to nerve growth factor stimulus] GO:2001214 [positive regulation of vasculogenesis]
