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CAPZA1

GENERAL INFORMATION

Gene name

 CAPZA1

Gene description

 Capping protein (actin filament) muscle Z-line, alpha 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB045963
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB045963

GENE INFORMATION

Gene name

 CAPZA1

Synonyms

Description

 Capping protein (actin filament) muscle Z-line, alpha 1 (HGNC Symbol)

Entrez gene summary

 CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p13.2

Chromosome location (bp)

 112619173 - 112671619

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116489 (version 83.38)

Entrez gene

 829

UniProt

 P52907 (UniProt - Evidence at protein level)

neXtProt

 NX_P52907

Antibodypedia

 CAPZA1 antibodies

PROTEIN BROWSER
CAPZA1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAPZA1-001
ENSP00000263168
ENST00000263168
P52907 [Direct mapping]
F-actin-capping protein subunit alpha-1
A0A024R0E5 [Target identity:100%; Query identity:100%]
Capping protein (Actin filament) muscle Z-line, alpha 1, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006461 [protein complex assembly]
GO:0006928 [movement of cell or subcellular component]
GO:0007596 [blood coagulation]
GO:0008290 [F-actin capping protein complex]
GO:0015629 [actin cytoskeleton]
GO:0045087 [innate immune response]
GO:0051016 [barbed-end actin filament capping]
GO:0070062 [extracellular exosome]
GO:0071203 [WASH complex]
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 286 aa
32.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.