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Moderate to strong cytoplasmic immunoreactivity was observed in most cancer tissues. Additional membranous staining was showed in colorectal and thyroid cancers. Pancreatic cancers showed additional nuclear staining.
GENE INFORMATION
Gene name
RNF19B (HGNC Symbol)
Synonyms
FLJ90005, IBRDC3
Description
Ring finger protein 19B (HGNC Symbol)
Entrez gene summary
This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protin is an E3 ubiquitin-protein ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region. [provided by RefSeq, Jul 2014]