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MEF2D

GENERAL INFORMATION

Gene name

 MEF2D

Gene description

 Myocyte enhancer factor 2D

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA004807 , HPA007114
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MEF2D

Synonyms

Description

 Myocyte enhancer factor 2D (HGNC Symbol)

Entrez gene summary

 This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Chromosome

 1

Cytoband

 q22

Chromosome location (bp)

 156463727 - 156500828

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116604 (version 83.38)

Entrez gene

 4209

UniProt

 Q14814 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14814

Antibodypedia

 MEF2D antibodies

PROTEIN BROWSER
MEF2D-001
MEF2D-004
MEF2D-005
MEF2D-006
MEF2D-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MEF2D-001
ENSP00000271555
ENST00000348159
Q14814 [Direct mapping]
Myocyte-specific enhancer factor 2D
Show all
Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001649 [osteoblast differentiation]
GO:0001958 [endochondral ossification]
GO:0002062 [chondrocyte differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007399 [nervous system development]
GO:0007512 [adult heart development]
GO:0007517 [muscle organ development]
GO:0019899 [enzyme binding]
GO:0033613 [activating transcription factor binding]
GO:0035914 [skeletal muscle cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
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 521 aa
55.9 kDa 		No 0
MEF2D-004
ENSP00000353803
ENST00000360595
Q14814 [Direct mapping]
Myocyte-specific enhancer factor 2D
Show all
Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007399 [nervous system development]
GO:0007512 [adult heart development]
GO:0007517 [muscle organ development]
GO:0033613 [activating transcription factor binding]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
Show all
 514 aa
55.1 kDa 		No 0
MEF2D-005
ENSP00000476788
ENST00000464356
Q14814 [Direct mapping]
Myocyte-specific enhancer factor 2D
Show all
Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007399 [nervous system development]
GO:0007512 [adult heart development]
GO:0007517 [muscle organ development]
GO:0033613 [activating transcription factor binding]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
Show all
 513 aa
55.3 kDa 		No 0
MEF2D-006
ENSP00000477124
ENST00000489057
A0A0G2JLL8 [Direct mapping]
Myocyte-specific enhancer factor 2D
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 10 aa
1.3 kDa 		No 0
MEF2D-201
ENSP00000357223
ENST00000368240
Q05BX2 [Direct mapping]
MEF2D protein; Myocyte-specific enhancer factor 2D
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 139 aa
16.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.